{"id":"W2100122430","doi":"10.1124/jpet.105.084053","title":"Xrcc3 Induces Cisplatin Resistance by Stimulation of Rad51-Related Recombinational Repair, S-Phase Checkpoint Activation, and Reduced Apoptosis","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"XRCC3; RAD51; Cisplatin; DNA repair; DNA damage; Homologous recombination; Cell biology; Cell cycle; Biology; G2-M DNA damage checkpoint; Cell cycle checkpoint; Apoptosis; CHEK1; ERCC1; DNA repair protein XRCC4; DNA; Cancer research; Molecular biology; Nucleotide excision repair; Genetics; Gene; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814447,0.0004436162,0.0005791037,0.0004522628,0.0002470759,0.0004032439,0.0003067322,0.0003981506,0.003289016],"category_scores_gemma":[0.000214747,0.0002933989,0.0004373161,0.0003460079,0.0003494902,0.0002283287,0.0002318676,0.001264797,0.0006074651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005027671,"about_ca_system_score_gemma":0.0004282262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006388958,"about_ca_topic_score_gemma":0.0009764378,"domain_scores_codex":[0.9997702,0.00004338636,0.0000298034,0.00003290628,0.00005486857,0.00006882881],"domain_scores_gemma":[0.9997841,0.00003011329,0.0000622638,0.00005351115,0.00001926049,0.000050779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007995273,0.0001086996,0.0002249917,0.00003110998,0.00001386697,0.00007857637,0.00001052597,0.00006046261,0.9970123,0.000104493,0.0001492811,0.00140617],"study_design_scores_gemma":[0.0001330792,0.0009931815,0.006339882,0.000004936639,0.00002581027,0.0004685054,0.00001579662,0.0004490133,0.9901142,0.00006034066,0.001388293,0.000006994044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947455,0.001369882,0.001351702,0.0002250518,0.00006357814,0.00007668901,0.0005030757,0.0002597728,0.001404829],"genre_scores_gemma":[0.9959874,0.0005051615,0.0005478468,0.00006230357,0.00001648829,0.00005796796,0.0006925145,0.00003676696,0.002093546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003289016,"threshold_uncertainty_score":0.01100284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161911758689882,"score_gpt":0.3314615876678481,"score_spread":0.3152704117988598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}