{"id":"W2100122430","doi":"10.1124/jpet.105.084053","title":"Xrcc3 Induces Cisplatin Resistance by Stimulation of Rad51-Related Recombinational Repair, S-Phase Checkpoint Activation, and Reduced Apoptosis","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"XRCC3; RAD51; Cisplatin; DNA repair; DNA damage; Homologous recombination; Cell biology; Cell cycle; Biology; G2-M DNA damage checkpoint; Cell cycle checkpoint; Apoptosis; CHEK1; ERCC1; DNA repair protein XRCC4; DNA; Cancer research; Molecular biology; Nucleotide excision repair; Genetics; Gene; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002827107,0.0001181105,0.0001690871,0.00006141245,0.00007252955,0.000007578039,0.00006912975,0.0001441767,0.00005835653],"category_scores_gemma":[0.00001198022,0.000113003,0.00006267194,0.00005813018,0.0001057364,0.00002692803,0.00003282773,0.000122792,2.794326e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003645963,"about_ca_system_score_gemma":0.00004991938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.081542e-7,"about_ca_topic_score_gemma":1.939861e-7,"domain_scores_codex":[0.9990837,0.0001051368,0.0004365943,0.0001468065,0.0001217438,0.0001060404],"domain_scores_gemma":[0.9993371,0.00003065996,0.0004118798,0.0000577738,0.0001117,0.00005085065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008750561,0.0004352246,0.00003839947,0.000008015941,0.0002594157,4.302969e-7,0.0003167985,0.00003095061,0.9952393,0.00007662083,0.00130209,0.001417663],"study_design_scores_gemma":[0.0036906,0.0007783373,0.000111656,0.00001321096,0.00006451295,0.00002267388,0.0001717015,0.0003470129,0.9911709,0.0001503283,0.003373419,0.0001056405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956676,0.003146723,0.0001413592,0.0006538638,0.0001743937,0.0001184176,0.000006386782,0.000005972933,0.00008533538],"genre_scores_gemma":[0.9963785,0.0004075983,0.002516416,0.0003969456,0.00009035423,0.000004533895,0.00001838508,0.00001257559,0.0001746869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00406843,"threshold_uncertainty_score":0.4608128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161911758689882,"score_gpt":0.3314615876678481,"score_spread":0.3152704117988598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}