{"id":"W2100141750","doi":"10.1073/pnas.1018927108","title":"Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Australian Research Council; Medical Research Council; Australian Synchrotron; Commonwealth Scientific and Industrial Research Organisation","keywords":"Cofilin; Protein filament; Actin remodeling; Actin-binding protein; Biology; Actin; Cell biology; Plasmodium falciparum; MDia1; Cytoskeleton; Microfilament; Actin cytoskeleton; Biophysics; Biochemistry; Cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009203724,0.0002718092,0.0002142703,0.0001670252,0.0002505002,0.000254426,0.0002943812,0.0001830572,0.0006077071],"category_scores_gemma":[0.0002528884,0.0001987184,0.0001386854,0.0001262845,0.0001872239,0.0001392789,0.0001584648,0.0004384615,0.0001589894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004781261,"about_ca_system_score_gemma":0.0002371954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663733,"about_ca_topic_score_gemma":0.002162121,"domain_scores_codex":[0.999899,0.00001385721,0.000008548424,0.00001603648,0.00003786396,0.00002462398],"domain_scores_gemma":[0.9998646,0.00003163724,0.00004861086,0.000006264774,0.00001398018,0.00003494037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001162641,0.00003850188,0.0007892027,0.00003322563,0.000005095505,0.00007686293,0.00001675058,0.0007084474,0.9973438,0.0001619361,0.00005336324,0.0006564354],"study_design_scores_gemma":[0.00003453201,0.0003016726,0.02043094,0.00001482366,0.00002663891,0.0005448387,0.00007330505,0.0109446,0.9642223,0.0002857549,0.003094895,0.00002580081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986743,0.0002379053,0.0005020296,0.00003063376,0.000002523232,0.00000770011,0.000141128,0.00001911511,0.000384724],"genre_scores_gemma":[0.9978597,0.0001885211,0.00109114,0.00001591586,0.00000277724,0.0000146859,0.0006421848,0.00001336172,0.0001718465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663733,"threshold_uncertainty_score":0.00346899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1433699128485836,"score_gpt":0.3975216191067701,"score_spread":0.2541517062581865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}