{"id":"W2100145928","doi":"10.1128/jvi.02495-05","title":"Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKε Molecular Complex from the Mitochondrial Outer Membrane by Hepatitis C Virus NS3-4A Proteolytic Cleavage","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; NS3; Cell biology; Transmembrane domain; Molecular biology; Virology; Hepatitis C virus; Biochemistry; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003067248,0.0002082135,0.0006345674,0.0001011848,0.0001123093,0.00001824215,0.0004061538,0.0003516939,0.0006609036],"category_scores_gemma":[0.0001623886,0.0001466472,0.0003441967,0.00007265405,0.000334809,0.00009586288,0.00007997629,0.0005256723,0.0001211493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006682185,"about_ca_system_score_gemma":0.00006699504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408526,"about_ca_topic_score_gemma":0.0002008202,"domain_scores_codex":[0.9974936,0.001043309,0.0008576228,0.000177715,0.0001001682,0.000327632],"domain_scores_gemma":[0.9983363,0.0004095535,0.0008290446,0.0002628885,0.0001420389,0.00002022859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002000576,0.0002115035,0.001975127,0.000005921733,0.0004603662,0.00003258233,0.0002495623,0.000008981204,0.9647615,0.0001364298,0.02950704,0.0006504026],"study_design_scores_gemma":[0.00380623,0.001431276,0.077443,0.00003854002,0.0002708418,0.0003005913,0.00008180443,0.00001318876,0.8776969,0.0006275481,0.03808465,0.0002054367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921331,0.002694574,0.001469854,0.001703691,0.001209116,0.0002695182,0.0002015201,0.00001223343,0.0003064285],"genre_scores_gemma":[0.9981704,0.0001472524,0.0002169599,0.0006545702,0.0001948025,0.0000084797,0.00009963011,0.00002279067,0.0004850905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08706462,"threshold_uncertainty_score":0.7236431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006215632620372678,"score_gpt":0.2200340281719304,"score_spread":0.2138183955515577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}