{"id":"W2100145928","doi":"10.1128/jvi.02495-05","title":"Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKε Molecular Complex from the Mitochondrial Outer Membrane by Hepatitis C Virus NS3-4A Proteolytic Cleavage","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; NS3; Cell biology; Transmembrane domain; Molecular biology; Virology; Hepatitis C virus; Biochemistry; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260467,0.0002991879,0.0002539924,0.0002859808,0.0001997503,0.0003321312,0.0003238089,0.000234998,0.001221509],"category_scores_gemma":[0.0001499214,0.0001766894,0.0003714805,0.0001533972,0.0001818185,0.0003027136,0.0002939827,0.0005153291,0.0005642317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008158128,"about_ca_system_score_gemma":0.0003589708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007410492,"about_ca_topic_score_gemma":0.0007500334,"domain_scores_codex":[0.9998688,0.000006514883,0.00001093442,0.00003530397,0.00004600112,0.00003247246],"domain_scores_gemma":[0.9999251,0.000009832454,0.00002190097,0.000008085965,0.000007012505,0.00002791773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009960858,0.0000177713,0.0005380401,0.00003596986,0.0000111807,0.000109029,0.00001899305,0.0001331534,0.9974559,0.0001447875,0.00007740166,0.001358128],"study_design_scores_gemma":[0.00001304343,0.00003596436,0.005168796,0.000004746782,0.00001006568,0.0003770264,0.00003097009,0.005010979,0.9875928,0.00007342749,0.001675389,0.00000681457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928983,0.0002096814,0.005526679,0.00007434882,0.00001572537,0.00001687488,0.000360199,0.0002233816,0.0006747558],"genre_scores_gemma":[0.9845483,0.0002224905,0.00954007,0.00006377146,0.000004034838,0.00004790279,0.002862964,0.0001615782,0.002548994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221509,"threshold_uncertainty_score":0.005919158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006215632620372678,"score_gpt":0.2200340281719304,"score_spread":0.2138183955515577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}