{"id":"W2100156364","doi":"10.1016/j.str.2015.02.001","title":"Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8","year":2015,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium; University of Toronto; McGill University","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust; Genome Canada","keywords":"Ankyrin repeat; Ankyrin; Genetics; Ubiquitin ligase; Biology; Histone; Transcription factor; Cell biology; PHD finger; Gene; Ubiquitin; Zinc finger","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333489,0.0002913859,0.0002831457,0.0002497299,0.0003525665,0.0003179498,0.0003598872,0.0004643002,0.002174389],"category_scores_gemma":[0.0002774812,0.0001694629,0.0003038641,0.0001554274,0.0002299921,0.0002673112,0.0003910696,0.0004685422,0.0007522925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005786713,"about_ca_system_score_gemma":0.0001897815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007032597,"about_ca_topic_score_gemma":0.001165593,"domain_scores_codex":[0.9998358,0.00003404226,0.00001250643,0.00004017544,0.00004559022,0.00003179543],"domain_scores_gemma":[0.9998214,0.00002259358,0.00006884035,0.00001781887,0.00002366387,0.00004563863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002483148,0.00002338693,0.003311777,0.00004108426,0.00002408078,0.001711587,0.00004579514,0.0002998544,0.9897915,0.0006663806,0.0004021737,0.003434176],"study_design_scores_gemma":[0.00005635163,0.0002781802,0.07870685,0.00002539928,0.00003974016,0.008100868,0.0001472578,0.006614603,0.8985117,0.0006608476,0.006827548,0.00003060929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945545,0.0005771779,0.003248574,0.0001342696,0.00002302763,0.00001011436,0.0001176247,0.00006677396,0.001267961],"genre_scores_gemma":[0.9964588,0.00009018597,0.001697346,0.00007540481,0.00001072742,0.000007734785,0.0002330084,0.00001152273,0.001415286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002174389,"threshold_uncertainty_score":0.007274032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02368204743930841,"score_gpt":0.2368759623614,"score_spread":0.2131939149220916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}