{"id":"W2100181546","doi":"10.1196/annals.1359.032","title":"Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM®640","year":2005,"lang":"en","type":"review","venue":"Annals of the New York Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"XIAP; Apoptosis; Inhibitor of apoptosis; Cancer research; Cancer; Cancer cell; Proteases; Programmed cell death; Caspase; Effector; Chemistry; Biology; Cell biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003749034,0.0007553606,0.0007419176,0.001414217,0.0001830294,0.0005105372,0.0006211326,0.0006710924,0.002355146],"category_scores_gemma":[0.0002527541,0.0002016918,0.0002543792,0.001011971,0.0003157802,0.0009383502,0.0003301168,0.001053289,0.002468655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005637564,"about_ca_system_score_gemma":0.0004997479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007599244,"about_ca_topic_score_gemma":0.001503428,"domain_scores_codex":[0.9999254,0.00001028464,0.00000895298,0.00001596321,0.00003122925,0.000008222896],"domain_scores_gemma":[0.9999275,0.00002335125,0.00001153963,0.000003560867,0.00002138571,0.00001261535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001173272,0.0000929702,0.0001342709,0.004654253,0.0000450854,0.0004307631,0.00004113768,0.0004727053,0.01028749,0.00346772,0.01688283,0.9633734],"study_design_scores_gemma":[0.00004192216,0.0001706828,0.000663142,0.000572738,0.00004457741,0.002194211,0.00002729379,0.0001001996,0.003573657,0.00108468,0.991513,0.00001400515],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008889016,0.99374,0.0007573323,0.0002917225,0.000305234,0.00001522195,0.00002563238,0.00002463594,0.003951331],"genre_scores_gemma":[0.002420497,0.9928858,0.0008022522,0.0002697589,0.0001181404,0.00001672731,0.00005404128,0.00000331416,0.003429587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002355146,"threshold_uncertainty_score":0.00787878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09102769500413634,"score_gpt":0.3916450076888963,"score_spread":0.30061731268476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}