{"id":"W2100204192","doi":"10.1158/1078-0432.ccr-07-1392","title":"Treatment of Human Colon Cancer Xenografts with TRA-8 Anti-death Receptor 5 Antibody Alone or in Combination with CPT-11","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"Daiichi Sankyo Europe; National Cancer Institute; National Institutes of Health","keywords":"Cytotoxicity; Apoptosis; In vivo; Cancer research; Flow cytometry; Monoclonal antibody; Cell culture; Biodistribution; Programmed cell death; Tumor necrosis factor alpha; Cancer; Colorectal cancer; Cancer cell; In vitro; Antibody; Molecular biology; Medicine; Pathology; Biology; Immunology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585354,0.0003397525,0.0004219259,0.0002085611,0.0001330098,0.0001996823,0.0001897581,0.0002334423,0.001088421],"category_scores_gemma":[0.0001041493,0.000118617,0.0002217587,0.0001637286,0.0001221196,0.0001561837,0.00008810493,0.0005156747,0.0003038522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004295589,"about_ca_system_score_gemma":0.0004355581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530741,"about_ca_topic_score_gemma":0.004186595,"domain_scores_codex":[0.9998889,0.00002353291,0.00001004493,0.00002315322,0.00002775915,0.0000266178],"domain_scores_gemma":[0.9999168,0.00001595422,0.00001784023,0.00001198187,0.00001226091,0.00002512011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001183977,0.0004732463,0.000845382,0.0001527404,0.00003836622,0.00008482089,0.00002695416,0.0004033355,0.9902506,0.0000440406,0.0002819896,0.006214429],"study_design_scores_gemma":[0.000341164,0.01298538,0.01103801,0.00001802477,0.0001044849,0.0006885625,0.00004941337,0.002381211,0.966932,0.00001591231,0.005433732,0.00001219272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994884,0.002509032,0.0006710689,0.00009590441,0.00007696287,0.00007094224,0.0002684202,0.0000562083,0.001367405],"genre_scores_gemma":[0.9924349,0.001899518,0.002490537,0.000060664,0.00002206238,0.00006415215,0.0007346966,0.00001007064,0.002283538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530741,"threshold_uncertainty_score":0.003641069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1609106821096213,"score_gpt":0.4847209567132256,"score_spread":0.3238102746036042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}