{"id":"W2100242214","doi":"10.1093/hmg/dds301","title":"Individual common variants exert weak effects on the risk for autism spectrum disorders","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":378,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta; University of Manitoba; McGill University; Memorial University of Newfoundland; McMaster University; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Ontario Ministry of Research and Innovation; Medical Research Council; Canadian Institutes of Health Research; Hospital for Sick Children; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Fondation de France; Health Research Board; National Institute for Health and Care Research; Ontario Genomics Institute; Fondation Orange; Koninklijke Nederlandse Akademie van Wetenschappen; Hussman Foundation; Autism Speaks; Sick Kids Foundation; National Institutes of Health; Ontario Genomics; Genome Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Science Foundation Ireland; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Ontario Innovation Trust; University of Toronto","keywords":"Single-nucleotide polymorphism; Autism; Genetics; Genome-wide association study; Genetic association; SNP; Allele; Biology; Genetic architecture; Genotyping; Minor allele frequency; Copy-number variation; Genotype; Gene; Phenotype; Genome; Psychology; Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005557248,0.0003363157,0.0002459002,0.0001546453,0.0008446454,0.000153883,0.0009979623,0.0001390432,0.000105363],"category_scores_gemma":[0.0002354542,0.0002741038,0.0001805668,0.0003194107,0.000239685,0.0000707211,0.0003466359,0.0005359595,0.0001998848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005522961,"about_ca_system_score_gemma":0.00003818567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003339622,"about_ca_topic_score_gemma":0.00004726857,"domain_scores_codex":[0.9965823,0.0006643471,0.0002701778,0.0005402795,0.0007918971,0.001150969],"domain_scores_gemma":[0.998018,0.0006466244,0.000148488,0.0009678601,0.000003205749,0.0002158324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000518771,0.000623707,0.008720919,0.00005719854,0.00006929552,0.00001499982,0.00107185,0.0001516208,0.109756,0.8739527,0.001244969,0.004284934],"study_design_scores_gemma":[0.001549778,0.001027903,0.2838134,0.0000374356,0.0001261818,0.00001238168,0.0000339094,0.0008226704,0.37936,0.325168,0.007348722,0.000699528],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828248,0.0006418636,0.004104242,0.005059341,0.0003507254,0.001988652,0.00005867059,0.0001124715,0.004859259],"genre_scores_gemma":[0.9981933,0.0001628143,0.0002023037,0.000837523,0.00009889328,0.0002154922,0.00001170646,0.000108785,0.0001692441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5487846,"threshold_uncertainty_score":0.9999711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02931493389406708,"score_gpt":0.2990565528502767,"score_spread":0.2697416189562096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}