{"id":"W2100266438","doi":"10.1128/aac.00474-11","title":"Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Centre for Disease Control","keywords":"Mycobacterium tuberculosis; Tuberculosis; Drug; Antibiotics; Pharmacology; Rifamycin; Antimicrobial; Spectinomycin; Medicine; Drug resistance; Biology; Microbiology; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000614428,0.001085416,0.001715588,0.001597297,0.0004797655,0.0008799893,0.0005634551,0.0006202366,0.003052575],"category_scores_gemma":[0.0005751607,0.0004147473,0.001112509,0.001307973,0.0002236167,0.0006007459,0.0007088874,0.0007757066,0.001281122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005051201,"about_ca_system_score_gemma":0.0007249905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003730535,"about_ca_topic_score_gemma":0.001544334,"domain_scores_codex":[0.9993343,0.0001304703,0.00005538608,0.000109755,0.0002928703,0.00007721195],"domain_scores_gemma":[0.9996835,0.00008757402,0.00005862001,0.00003456982,0.00008725698,0.00004849164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006017355,0.0006823273,0.002947034,0.00096107,0.000263395,0.0004822523,0.00004886776,0.003046879,0.94059,0.0004028469,0.003074923,0.04689861],"study_design_scores_gemma":[0.0004192205,0.006967652,0.01468212,0.0001237415,0.001464904,0.003332171,0.0001542243,0.01488643,0.9101761,0.0008043285,0.0468368,0.0001522959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8412034,0.04286892,0.06790041,0.002199151,0.0003558022,0.002565837,0.01553057,0.003840493,0.02353544],"genre_scores_gemma":[0.9101381,0.01963471,0.05053786,0.0009763619,0.0001578943,0.001047591,0.01089721,0.000151177,0.006459116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003052575,"threshold_uncertainty_score":0.01021183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04706576553618031,"score_gpt":0.30574643855367,"score_spread":0.2586806730174897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}