{"id":"W2100266438","doi":"10.1128/aac.00474-11","title":"Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Centre for Disease Control","keywords":"Mycobacterium tuberculosis; Tuberculosis; Drug; Antibiotics; Pharmacology; Rifamycin; Antimicrobial; Spectinomycin; Medicine; Drug resistance; Biology; Microbiology; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002825387,0.000248707,0.0004759454,0.0001039271,0.0002257597,0.00003617062,0.0001539517,0.000141817,0.0003873179],"category_scores_gemma":[0.00005293565,0.0002027401,0.0001696747,0.0001500777,0.0002062714,0.0001097262,0.0000349643,0.0001524386,0.00002056492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003533168,"about_ca_system_score_gemma":0.00004023398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001898828,"about_ca_topic_score_gemma":0.0000358476,"domain_scores_codex":[0.9984935,0.00004541125,0.000354235,0.0004690114,0.0001420343,0.0004958435],"domain_scores_gemma":[0.999164,0.0001020566,0.00009257162,0.0002941821,0.0001397754,0.0002074536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001121436,0.002470655,0.01510637,0.000100317,0.0009155679,0.000007952237,0.00087209,4.220925e-7,0.138574,0.001685878,0.8297131,0.009432168],"study_design_scores_gemma":[0.05181796,0.002154419,0.3596113,0.0003322992,0.0004163955,0.0001215519,0.0002655917,0.001006046,0.2387394,0.002688843,0.3412609,0.001585299],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786348,0.0001365481,0.003132938,0.01602085,0.0001633806,0.0009700987,0.0002480638,0.00007266692,0.0006206046],"genre_scores_gemma":[0.9666931,0.004038976,0.002651416,0.02397347,0.0001316852,0.0000674153,0.0003765237,0.00006034186,0.00200705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4884522,"threshold_uncertainty_score":0.82675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04706576553618031,"score_gpt":0.30574643855367,"score_spread":0.2586806730174897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}