{"id":"W2100285058","doi":"10.1128/mmbr.70.1.12-36.2006","title":"Structural Perspective on Mutations Affecting the Function of Multisubunit RNA Polymerases","year":2006,"lang":"en","type":"review","venue":"Microbiology and Molecular Biology Reviews","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Genome Canada","keywords":"Processivity; Biology; RNA polymerase; Transcription (linguistics); Genetics; Polymerase; Proofreading; RNA; RNA polymerase II; Cell biology; Computational biology; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004757567,0.000545703,0.001310262,0.0001201392,0.0002258003,0.00001218523,0.0003205408,0.0007886509,0.00002178703],"category_scores_gemma":[0.0002347276,0.0003321732,0.0006093549,0.0001484467,0.0004673881,0.000002448116,0.0001453647,0.0003145228,0.00001614306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002299998,"about_ca_system_score_gemma":0.00008365497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003590618,"about_ca_topic_score_gemma":0.00002211748,"domain_scores_codex":[0.9965736,0.001698029,0.000658762,0.0007183537,0.00002787958,0.0003234288],"domain_scores_gemma":[0.998489,0.0001392916,0.0007015764,0.0005526762,0.00007415281,0.00004333018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003959559,0.00003286251,0.000005241658,0.00105125,0.0004104217,0.000003091714,0.00002103433,7.414656e-7,0.4506304,0.0020919,0.0002379563,0.5454755],"study_design_scores_gemma":[0.0002515092,0.0007511104,0.000003157266,0.001172232,0.0008072816,0.0001792526,0.00003204346,2.46991e-7,0.02985757,0.0003084702,0.9661653,0.0004718105],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002020799,0.9948577,0.000999513,0.00003399817,0.0002778978,0.001379328,0.0001650176,0.00001046642,0.0002552347],"genre_scores_gemma":[0.003025597,0.9946442,0.000293534,0.0002284424,0.000175187,0.0001924681,0.001228911,0.00004634063,0.0001653292],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9659274,"threshold_uncertainty_score":0.999913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400676433837433,"score_gpt":0.3204460107385118,"score_spread":0.2964392464001374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}