{"id":"W2100303008","doi":"10.1371/journal.ppat.1003147","title":"An Upstream Open Reading Frame Modulates Ebola Virus Polymerase Translation and Virus Replication","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; York University","keywords":"Biology; Five prime untranslated region; Untranslated region; Virology; Open reading frame; Internal ribosome entry site; Translation (biology); Viral replication; Polymerase; Upstream open reading frame; Three prime untranslated region; Virus; Molecular biology; Messenger RNA; Gene; Genetics; Peptide sequence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916368,0.0001336656,0.0002106465,0.0001366777,0.0001993242,0.0001718231,0.00009994431,0.0001156772,0.0004293568],"category_scores_gemma":[0.0000584871,0.0001138643,0.00004242267,0.0001996439,0.00005176293,0.0004626551,0.00004261652,0.0001765694,0.0001310079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003870041,"about_ca_system_score_gemma":0.00003624785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002413632,"about_ca_topic_score_gemma":0.00006494173,"domain_scores_codex":[0.9988649,0.00007619771,0.0002226989,0.0004155219,0.0001815799,0.0002391379],"domain_scores_gemma":[0.9990056,0.00004439227,0.00005275483,0.0005388284,0.0001191358,0.0002393163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005031731,0.0002618324,0.006068907,0.00002077939,0.00003307965,0.000005440033,0.0002934716,0.000003730272,0.8933052,0.00006391067,0.0000578732,0.09983549],"study_design_scores_gemma":[0.001261861,0.0008287823,0.09114449,0.0001052856,0.0001501421,0.00007910694,0.0002153811,0.05164475,0.8529276,0.0005623754,0.0007723963,0.0003078845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953905,0.0002077208,0.0004448807,0.0005797999,0.00002169032,0.001027703,0.0000518295,0.00008969422,0.002186228],"genre_scores_gemma":[0.9971437,0.0001807386,0.001697572,0.000245633,0.0001159579,0.000169735,0.000124491,0.00003277186,0.0002893342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0995276,"threshold_uncertainty_score":0.4701157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0591309859209076,"score_gpt":0.3446433266652504,"score_spread":0.2855123407443428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}