{"id":"W2100381809","doi":"10.1186/s12944-015-0090-6","title":"α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways","year":2015,"lang":"en","type":"article","venue":"Lipids in Health and Disease","topic":"Fatty Acid Research and Health","field":"Nursing","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Docosahexaenoic acid; Apoptosis; Protein kinase B; Cell growth; Docosapentaenoic acid; Phospholipid; Fatty acid; Biology; Biochemistry; Chemistry; Polyunsaturated fatty acid; Pharmacology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000600986,0.0004111188,0.0006159655,0.0001623888,0.0005455263,0.0002202267,0.0001545936,0.0001342149,0.00002415588],"category_scores_gemma":[0.0001148963,0.0003479442,0.00004141518,0.0002367879,0.0003119339,0.0004392639,0.0001189692,0.0005546417,0.000001510341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003326607,"about_ca_system_score_gemma":0.001158515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004069098,"about_ca_topic_score_gemma":0.000834528,"domain_scores_codex":[0.99638,0.0005436643,0.0005847127,0.0007946719,0.0005407786,0.001156115],"domain_scores_gemma":[0.9951853,0.0001225921,0.0002189163,0.0003285622,0.0001323832,0.004012215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1596326,0.004754317,0.528883,0.03968474,0.0001923432,0.0004195627,0.029539,0.0002210476,0.06982008,0.0009658132,0.004793691,0.1610938],"study_design_scores_gemma":[0.07086805,0.01254446,0.8390409,0.01266071,0.0003134556,0.0002648666,0.01106333,0.01229759,0.02499705,0.01161754,0.0005636587,0.003768341],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751007,0.01756109,0.00009258602,0.005587676,0.0003027028,0.0009571729,0.0002503938,0.00009327965,0.00005439325],"genre_scores_gemma":[0.9952375,0.002028931,0.0007540224,0.001348161,0.0003918812,0.00008686882,0.00006064484,0.00006345729,0.00002849059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.310158,"threshold_uncertainty_score":0.9998972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704201275179247,"score_gpt":0.2845078330248443,"score_spread":0.2574658202730519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}