{"id":"W2100382777","doi":"10.1084/jem.191.9.1525","title":"Degradation of Transcription Factor Rfx5 during the Inhibition of Both Constitutive and Interferon γ–Inducible Major Histocompatibility Complex Class I Expression in Chlamydia-Infected Cells","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Biology; Proteasome; MHC class I; Transcription factor; Major histocompatibility complex; MHC class II; Lactacystin; Interferon; Cell biology; Interferon gamma; Proteasome inhibitor; Immunology; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868978,0.0002707405,0.0002612145,0.0001013035,0.0001652833,0.0003596327,0.0001282869,0.0001518961,0.00064724],"category_scores_gemma":[0.0001532086,0.0001126481,0.0002141079,0.00009937573,0.0001861734,0.0001409462,0.0001420589,0.0003515948,0.0003566759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000427247,"about_ca_system_score_gemma":0.0002643177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132229,"about_ca_topic_score_gemma":0.001131751,"domain_scores_codex":[0.9998703,0.00001790351,0.00001534477,0.00002441554,0.00003110424,0.00004093168],"domain_scores_gemma":[0.9998896,0.00002629999,0.00002530314,0.00002310709,0.0000134877,0.00002218054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007012855,0.000009100759,0.0001476149,0.00002170715,0.000002449646,0.00002583357,0.00001353252,0.00002287551,0.9989937,0.00005533607,0.00001928329,0.0006184183],"study_design_scores_gemma":[0.000008883419,0.0001309327,0.005459037,0.000005507083,0.000007093592,0.0001792284,0.00001687107,0.0004757716,0.9924269,0.00002025072,0.001266812,0.000002790202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992597,0.00365094,0.00213302,0.00007095027,0.00002582608,0.00001520194,0.0003490785,0.0000447529,0.001113182],"genre_scores_gemma":[0.9949014,0.0009060298,0.001313834,0.00003867111,0.00000921197,0.00001625529,0.0006919323,0.00001196497,0.00211066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132229,"threshold_uncertainty_score":0.003099918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.035533749860332,"score_gpt":0.3079132105860328,"score_spread":0.2723794607257007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}