{"id":"W2100409593","doi":"10.4161/chan.5112","title":"Docking of μ-Conotoxin GIIIA in the Sodium Channel Outer Vestibule","year":2007,"lang":"en","type":"article","venue":"Channels","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Biophysics; Chemistry; Docking (animal); Vestibule; Mutant; Sodium channel; Gene isoform; Toxin; Voltage clamp; Alanine; Binding site; Stereochemistry; Biochemistry; Amino acid; Biology; Sodium; Membrane potential; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000871075,0.0001418537,0.0001632936,0.00005764216,0.00004124889,0.00001125266,0.0003455527,0.0001307705,0.00001303019],"category_scores_gemma":[0.0001028912,0.0001090807,0.00007463012,0.000140543,0.00007451712,0.000003554064,0.0001319396,0.0001312287,0.00001291676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001134648,"about_ca_system_score_gemma":0.00002821221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003359095,"about_ca_topic_score_gemma":0.00005173561,"domain_scores_codex":[0.9989251,0.0000534218,0.0002974652,0.0002581479,0.0001335895,0.0003322881],"domain_scores_gemma":[0.9994193,0.0000345379,0.0001036901,0.00035074,0.00004937559,0.00004234176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003387757,0.0009362592,0.01414494,0.0001120627,0.0001587399,0.00001576177,0.008460177,0.000548639,0.9581113,0.0004478309,0.009691729,0.00703375],"study_design_scores_gemma":[0.0009858332,0.0002694216,0.002178611,0.00003060955,0.00001220757,0.00002442291,0.001057769,0.00007759334,0.9805385,0.000163477,0.01442563,0.0002359264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944661,0.0004452741,0.001790615,0.0002858139,0.0004379413,0.0002939606,0.000005592357,0.000007833045,0.002266912],"genre_scores_gemma":[0.9985147,0.00003443725,0.0001031773,0.0004165978,0.0006010957,0.00001660853,0.00002349075,0.00001894018,0.0002709566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02242717,"threshold_uncertainty_score":0.4448183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693191497077757,"score_gpt":0.2806103323725851,"score_spread":0.2636784174018075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}