{"id":"W2100409593","doi":"10.4161/chan.5112","title":"Docking of μ-Conotoxin GIIIA in the Sodium Channel Outer Vestibule","year":2007,"lang":"en","type":"article","venue":"Channels","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Biophysics; Chemistry; Docking (animal); Vestibule; Mutant; Sodium channel; Gene isoform; Toxin; Voltage clamp; Alanine; Binding site; Stereochemistry; Biochemistry; Amino acid; Biology; Sodium; Membrane potential; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007035832,0.0002622913,0.0002290446,0.0001443138,0.0001810271,0.0002973339,0.000352442,0.0001894389,0.0008504142],"category_scores_gemma":[0.0002884307,0.0001319652,0.0001654944,0.00009954542,0.0001995597,0.0001398401,0.0002661737,0.0002862689,0.0001714975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006235993,"about_ca_system_score_gemma":0.0005370273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003555529,"about_ca_topic_score_gemma":0.003571215,"domain_scores_codex":[0.9999428,0.000008002062,0.000002201358,0.000009473312,0.00002124405,0.00001633797],"domain_scores_gemma":[0.999946,0.00001101607,0.00001041234,0.000003646362,0.000007078708,0.0000219832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008797017,0.0002184265,0.009184404,0.0000726517,0.00008125787,0.0005266934,0.000101081,0.2704529,0.7061566,0.002372179,0.0001938704,0.009760291],"study_design_scores_gemma":[0.0001143758,0.0007363321,0.004736699,0.0000151892,0.00004075343,0.0001198298,0.0001442431,0.8204081,0.1721215,0.0005979593,0.0009340559,0.00003106579],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976617,0.00001912823,0.001771902,0.00001122075,0.000003194054,0.000007627827,0.00001804406,0.00002372245,0.0004834654],"genre_scores_gemma":[0.9978663,0.00004835195,0.001709279,0.000008695309,5.130009e-7,0.000007030215,0.00005880867,0.00001085354,0.0002901383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003555529,"threshold_uncertainty_score":0.007069707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693191497077757,"score_gpt":0.2806103323725851,"score_spread":0.2636784174018075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}