{"id":"W2100410594","doi":"10.4049/jimmunol.1002780","title":"The P2X7 Receptor and Pannexin-1 Are Both Required for the Promotion of Multinucleated Macrophages by the Inflammatory Cytokine GM-CSF","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Università degli Studi di Ferrara; Associazione Italiana per la Ricerca sul Cancro","keywords":"Cell biology; Ectodomain; Extracellular; Cytokine; Receptor; Biology; Cell fusion; Chemistry; Pharmacology; Cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008985954,0.000111168,0.0001449054,0.00001640416,0.0002911153,0.00001165146,0.0004530047,0.0001001538,0.00001561075],"category_scores_gemma":[0.000207532,0.00004452743,0.00008083864,0.00004529022,0.0004215615,0.000007109362,0.0001035563,0.0001720971,8.787624e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006796095,"about_ca_system_score_gemma":0.00003416018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002057621,"about_ca_topic_score_gemma":0.000004742754,"domain_scores_codex":[0.9990702,0.0002580043,0.0003486447,0.00007830148,0.00007692829,0.0001679671],"domain_scores_gemma":[0.998714,0.0001948926,0.0005996847,0.0002751869,0.0001990819,0.00001719569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001362882,0.00004195525,0.0002805205,0.000008737307,0.0003911791,0.000001039553,0.0006519171,0.00001126948,0.9841031,0.00004660942,0.009550806,0.003549935],"study_design_scores_gemma":[0.001944975,0.002010085,0.01037679,0.00005791778,0.0002337932,0.0003614907,0.003454326,0.00007511979,0.944579,0.0004021793,0.03634363,0.0001606793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720761,0.02524074,0.0005127215,0.00170545,0.0001872124,0.0002271852,0.00001302762,0.000003015528,0.00003454699],"genre_scores_gemma":[0.9953421,0.003933164,0.00007699135,0.00009372769,0.0001681182,0.000007872651,0.00000359375,0.00001612016,0.00035826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03952414,"threshold_uncertainty_score":0.2239053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654743303090984,"score_gpt":0.2303481026018792,"score_spread":0.2138006695709694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}