{"id":"W2100442826","doi":"10.3899/jrheum.110092","title":"Safety and Efficacy of Febuxostat Treatment in Subjects with Gout and Severe Allopurinol Adverse Reactions","year":2011,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Allopurinol; Medicine; Gout; Febuxostat; Xanthine oxidase inhibitor; Rash; Exfoliative dermatitis; Xanthine oxidase; Adverse effect; Internal medicine; Dermatology; Toxic epidermal necrolysis; Surgery; Gastroenterology; Hyperuricemia; Uric acid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002018258,0.0002460249,0.0007177746,0.0004399712,0.0003961088,0.0004039655,0.0001318132,0.0004484314,0.0009727376],"category_scores_gemma":[0.003708092,0.000111986,0.0005534558,0.0003762173,0.0003481494,0.0002181457,0.0001816502,0.0003704542,0.0001907497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001789445,"about_ca_system_score_gemma":0.0001904596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001736657,"about_ca_topic_score_gemma":0.0002347866,"domain_scores_codex":[0.9988559,0.0005907753,0.0001706363,0.0001279352,0.0001863515,0.00006832398],"domain_scores_gemma":[0.9964161,0.001277178,0.001633237,0.0001975901,0.0002173089,0.0002586528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03786164,0.001149221,0.8536762,0.0005476962,0.0006622045,0.001860332,0.0004417679,0.0004197655,0.01289818,0.0001126775,0.0003007049,0.09006965],"study_design_scores_gemma":[0.00154711,0.04616867,0.9380434,0.00009859489,0.0005174854,0.006940514,0.0001808593,0.0007160393,0.003572959,0.0001077303,0.002084438,0.00002223845],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951031,0.003466105,0.0002862587,0.00005345832,0.000009261073,0.00006029701,0.0001261355,0.00001152739,0.0008838226],"genre_scores_gemma":[0.9992027,0.0003167311,0.0001717432,0.00006132879,0.00003738339,0.00002000186,0.0001108593,0.000001376652,0.00007789592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018258,"threshold_uncertainty_score":0.0106737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691314907692774,"score_gpt":0.2426496525853787,"score_spread":0.225736503508451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}