{"id":"W2100459284","doi":"10.1158/1940-6207.capr-13-0403","title":"The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin","year":2014,"lang":"en","type":"article","venue":"Cancer Prevention Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; Cell migration; Cell; Actin; Stress fiber; Cell biology; Cancer research; Cytoskeleton; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008621225,0.0002647326,0.0001670803,0.0002112231,0.000121958,0.0001101523,0.000166473,0.0001583325,0.001221009],"category_scores_gemma":[0.00009114636,0.0000916934,0.00009573819,0.0001656176,0.0001465717,0.00008206108,0.0001249816,0.0002574852,0.00027981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462686,"about_ca_system_score_gemma":0.0001769354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008511709,"about_ca_topic_score_gemma":0.002622714,"domain_scores_codex":[0.9999286,0.00001681049,0.0000066851,0.000008537646,0.0000203273,0.00001901631],"domain_scores_gemma":[0.9999454,0.000008437467,0.00001335108,0.000005296484,0.000009046455,0.00001839706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001882279,0.00005523846,0.0002672866,0.00009780038,0.00001120455,0.00006428271,0.000008718107,0.0002204657,0.9946548,0.00009983152,0.0001280142,0.004204291],"study_design_scores_gemma":[0.00004611615,0.001389906,0.004820425,0.00001156025,0.00002086931,0.0003250176,0.00002166582,0.0005402168,0.9878212,0.00003292584,0.004962249,0.000007792461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837728,0.009449081,0.001446668,0.0001201062,0.00005019973,0.00005713046,0.0002893057,0.00005427895,0.004760406],"genre_scores_gemma":[0.9927898,0.003633628,0.0009274274,0.00005733269,0.00001003928,0.00002559874,0.0003331268,0.000004785127,0.002218253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221009,"threshold_uncertainty_score":0.004084647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03731259650262334,"score_gpt":0.3464998813379745,"score_spread":0.3091872848353512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}