{"id":"W2100472054","doi":"10.1101/gad.1291405","title":"3D reconstruction of the Mu transposase and the Type 1 transpososome: a structural framework for Mu DNA transposition","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto; Ontario Institute for Cancer Research; Western University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Transposase; Biology; Tetramer; DNA; Transposable element; Bacteriophage Mu; Transposition (logic); Biophysics; Genetics; Biochemistry; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893391,0.000134429,0.0001355036,0.00001702039,0.0001858864,0.00001151472,0.0001465629,0.0001362224,0.00001854038],"category_scores_gemma":[0.00001308605,0.00008222894,0.00008544404,0.00006280121,0.0001121079,0.00000503092,0.000009792434,0.0000500589,9.314498e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001044063,"about_ca_system_score_gemma":0.00008323804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003048387,"about_ca_topic_score_gemma":0.00003810454,"domain_scores_codex":[0.9992263,0.00006574347,0.0002420508,0.0002076145,0.0001047715,0.0001535481],"domain_scores_gemma":[0.9996225,0.00002649026,0.00007808982,0.0001841251,0.00005661801,0.0000322366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008315721,0.00001275726,0.000268674,0.00005152992,0.00009845572,1.288068e-7,0.001013962,0.00005578282,0.7463971,0.001250595,0.000008121924,0.2500113],"study_design_scores_gemma":[0.000859252,0.00006417598,0.002845269,0.00004767493,0.00005444448,0.00002211302,0.00007414758,0.00003353418,0.985806,0.001357002,0.008694632,0.000141695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797629,0.002015037,0.01625347,0.001057177,0.0002477206,0.0006049041,0.00002532704,0.000007037639,0.0000263951],"genre_scores_gemma":[0.9446958,0.0003715572,0.05435519,0.0002611652,0.0001337369,0.00008177517,0.00003183225,0.00001466116,0.00005423022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2498696,"threshold_uncertainty_score":0.3353199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008209327304317561,"score_gpt":0.2226812300691084,"score_spread":0.2144719027647909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}