{"id":"W2100472054","doi":"10.1101/gad.1291405","title":"3D reconstruction of the Mu transposase and the Type 1 transpososome: a structural framework for Mu DNA transposition","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto; Ontario Institute for Cancer Research; Western University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Transposase; Biology; Tetramer; DNA; Transposable element; Bacteriophage Mu; Transposition (logic); Biophysics; Genetics; Biochemistry; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001564168,0.0003842754,0.0002436676,0.000411202,0.0003158588,0.0008433584,0.0006174028,0.0008869084,0.002863367],"category_scores_gemma":[0.0004847723,0.0004401869,0.000373914,0.0002567282,0.0004423532,0.0004698751,0.0004301838,0.0007132324,0.0007543011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004585862,"about_ca_system_score_gemma":0.0005884971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001668414,"about_ca_topic_score_gemma":0.001504415,"domain_scores_codex":[0.9999282,0.00001482421,0.000004095492,0.00001106756,0.00003037496,0.00001136239],"domain_scores_gemma":[0.9999093,0.0000252016,0.00001086108,0.00002008783,0.00001971805,0.00001490155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003631783,0.0001252004,0.003339776,0.0003411718,0.00006877775,0.00167866,0.0007361574,0.3383479,0.5628369,0.05372638,0.00253453,0.03590142],"study_design_scores_gemma":[0.00005703357,0.0000903074,0.003884787,0.00006213032,0.00002774022,0.0009410571,0.0002751877,0.8958961,0.07555407,0.009756489,0.01337137,0.00008378492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5535935,0.0008541166,0.4283148,0.000978232,0.00008420443,0.000107817,0.001814515,0.00243597,0.01181679],"genre_scores_gemma":[0.8157125,0.001126312,0.1790504,0.00007251125,0.00001370136,0.00008153359,0.001002299,0.0003942742,0.00254649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002863367,"threshold_uncertainty_score":0.009578943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008209327304317561,"score_gpt":0.2226812300691084,"score_spread":0.2144719027647909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}