{"id":"W2100474560","doi":"10.1242/dmm.020859","title":"Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype","year":2015,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McMaster University; University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Phospholamban; SERCA; Internal medicine; Myopathy; Endocrinology; Biology; Endoplasmic reticulum; Sarcolemma; Skeletal muscle; ATPase; Cell biology; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160395,0.000202576,0.0001537753,0.00004164573,0.00005984386,0.00001695583,0.0002131256,0.0001363718,0.00003031605],"category_scores_gemma":[0.00004306274,0.0001988126,0.0000831524,0.00007246205,0.00004068262,0.00001627786,0.0001676899,0.00009762997,0.00003072204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002255324,"about_ca_system_score_gemma":0.0001553695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008315603,"about_ca_topic_score_gemma":0.00002494657,"domain_scores_codex":[0.9987465,0.00009146849,0.0001701042,0.0004749573,0.0001708466,0.0003461592],"domain_scores_gemma":[0.9991851,0.000005088755,0.00005922845,0.0003596311,0.00006006611,0.0003308561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003188284,0.0005645785,0.0002131959,0.00004394626,0.00003366794,0.00002475008,0.0003391581,0.01205249,0.9681128,0.01237795,0.002524705,0.0005244383],"study_design_scores_gemma":[0.01332336,0.001552784,0.004880359,0.0004155078,0.0001795682,0.000006974662,0.002058925,0.07659462,0.4064499,0.4841928,0.007535366,0.002809798],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908826,0.001158768,0.006838625,0.00007848263,0.0001685013,0.0002476446,0.000047057,0.00003240374,0.0005459523],"genre_scores_gemma":[0.9979252,0.00006400845,0.0004974332,0.001001253,0.00006408352,0.00004099529,0.0002339047,0.00003586834,0.0001373184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5616629,"threshold_uncertainty_score":0.8107341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171391812913015,"score_gpt":0.2352643295454305,"score_spread":0.218125148254129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}