{"id":"W2100503711","doi":"10.1096/fj.02-1053fje","title":"The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs","year":2003,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Japan Society for the Promotion of Science; Institut National de la Santé et de la Recherche Médicale","keywords":"Ceramide; Doxorubicin; Pharmacology; Cell culture; Sphingolipid; Apoptosis; Cytotoxicity; Chemistry; Melanoma; Biochemistry; Biology; Cancer research; In vitro; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135536,0.0002943756,0.0002210717,0.0001394765,0.00007814724,0.00026514,0.0001615879,0.0002237681,0.001227931],"category_scores_gemma":[0.0001402896,0.0001099906,0.0001383927,0.0001465971,0.0002459442,0.0001872912,0.0001711616,0.0005103854,0.0003687926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002348929,"about_ca_system_score_gemma":0.0002208545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008174252,"about_ca_topic_score_gemma":0.0008917281,"domain_scores_codex":[0.9998195,0.00004041951,0.00002100301,0.00003541148,0.00005485793,0.00002890358],"domain_scores_gemma":[0.999838,0.00003934976,0.00002968044,0.00004122034,0.00001631151,0.00003536135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003639195,0.000008278939,0.00010959,0.00001165398,0.000002455559,0.00002698047,0.000006267619,0.00002311949,0.9993117,0.00006007032,0.000008213822,0.0003952748],"study_design_scores_gemma":[0.000008906023,0.000173025,0.002086679,0.000003323754,0.000008354857,0.000260874,0.00002179097,0.0003890106,0.9951211,0.00003676379,0.001888009,0.000002275959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954862,0.0006481208,0.00142845,0.00005666328,0.00002435317,0.00002651202,0.0002971638,0.00004326906,0.001989233],"genre_scores_gemma":[0.9957647,0.0003664869,0.00144561,0.00002548696,0.000003682687,0.000027713,0.0005866573,0.00001516477,0.001764491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001227931,"threshold_uncertainty_score":0.004107893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009729782399874116,"score_gpt":0.2297963365020537,"score_spread":0.2200665541021795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}