{"id":"W2100512693","doi":"10.1128/aac.04435-14","title":"Multicenter Evaluation of MIC Distributions for Epidemiologic Cutoff Value Definition To Detect Amphotericin B, Posaconazole, and Itraconazole Resistance among the Most Clinically Relevant Species of Mucorales","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de Santé Publique du Québec","funders":"","keywords":"Posaconazole; Mucor circinelloides; Mucorales; Rhizopus arrhizus; Itraconazole; Biology; Microbiology; Broth microdilution; Etest; Rhizopus; Amphotericin B; Mucormycosis; Mucor; Medicine; Antifungal; Minimum inhibitory concentration; Aspergillus; Antibiotics; Food science; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01808201,0.0006156919,0.0004779694,0.00066041,0.0003124433,0.0007136987,0.0007604575,0.0004116138,0.0007321967],"category_scores_gemma":[0.009720968,0.0002092194,0.0003516271,0.0007291652,0.0003855323,0.0004254423,0.0006802544,0.0006160904,0.0002367072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007334013,"about_ca_system_score_gemma":0.001042666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001578633,"about_ca_topic_score_gemma":0.001116134,"domain_scores_codex":[0.9940527,0.003702026,0.0004004095,0.0008857088,0.0006749897,0.0002841444],"domain_scores_gemma":[0.9916762,0.001299969,0.001747376,0.00150834,0.002915314,0.0008527468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01924087,0.002864413,0.8715281,0.0001254281,0.0003007028,0.000121429,0.0005473378,0.001954844,0.04085689,0.0007442714,0.001821116,0.05989449],"study_design_scores_gemma":[0.001231362,0.02634867,0.9451327,0.00004699782,0.0002460979,0.0006456924,0.0003919996,0.005639416,0.0158542,0.0001608714,0.004268094,0.00003378991],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928036,0.0003905155,0.00413606,0.00007953297,0.00001489564,0.0004595339,0.0009858476,0.00007711592,0.001052823],"genre_scores_gemma":[0.9928369,0.00007588496,0.004489084,0.00006451633,0.0000116254,0.0002746261,0.002063342,0.00001759271,0.0001664704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01808201,"threshold_uncertainty_score":0.09562796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07906264482070478,"score_gpt":0.3441768967977435,"score_spread":0.2651142519770388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}