{"id":"W2100532651","doi":"10.1161/circulationaha.110.948570","title":"Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels","year":2011,"lang":"en","type":"review","venue":"Circulation","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":524,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gibson Energy (Canada)","funders":"Institute of Genetics; National Center for Research Resources; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; University of Texas MD Anderson Cancer Center; National Institutes of Health; Terveyden ja hyvinvoinnin laitos; Universität Greifswald; Hjartavernd; U.S. Department of Veterans Affairs; Office of Research and Development; Oulun Yliopisto; Universitair Medisch Centrum Groningen; Rijksuniversiteit Groningen; Universiteit Leiden; King's College London; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; University of Texas Health Science Center at Houston; Imperial College London; University of Washington; Helsingin Yliopisto; Cedars-Sinai Medical Center; National Institute of Diabetes and Digestive and Kidney Diseases; Biocenter, University of Oulu; Consiglio Nazionale delle Ricerche; Amgen; National Cancer Institute; Wake Forest University; Háskóli Íslands; University of Minnesota; British Heart Foundation; University of North Carolina at Chapel Hill; Brigham and Women's Hospital","keywords":"Genome-wide association study; Genetics; Genetic association; Single-nucleotide polymorphism; Medicine; Inflammation; Allele; C-reactive protein; Disease; Biology; Gene; Bioinformatics; Immunology; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001105079,0.0003933556,0.004229976,0.001170905,0.0000698185,0.00001793316,0.0001099887,0.0003083969,0.00009440415],"category_scores_gemma":[0.004882133,0.0003205746,0.002339177,0.001100555,0.00005636197,0.0002455446,0.00002660801,0.0001368301,0.00001024786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005208674,"about_ca_system_score_gemma":0.0002638803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008653199,"about_ca_topic_score_gemma":0.0002579234,"domain_scores_codex":[0.9971872,0.0002866133,0.001368393,0.0004841786,0.0004176323,0.0002559627],"domain_scores_gemma":[0.995417,0.001170875,0.001963917,0.0004282951,0.0009482811,0.00007164675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001462614,0.0007141053,0.04566052,0.05637513,0.848093,0.00001041214,0.006646207,0.0006307195,0.0001628917,0.0005233292,0.0001522668,0.04088517],"study_design_scores_gemma":[0.0007609958,0.00002534509,0.1333153,0.0008156115,0.7808412,9.804651e-7,0.000166427,0.00009141403,0.00005662059,0.0004093798,0.08309762,0.0004190472],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008670992,0.9855794,0.000834115,0.00001779988,0.0001061821,0.004241399,0.000416545,0.00003845444,0.00009507508],"genre_scores_gemma":[0.1865392,0.8011582,0.0004194165,0.00006134767,0.0004085144,0.004031978,0.005252802,0.0001272272,0.002001196],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1844212,"threshold_uncertainty_score":0.9999247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2291620671851327,"score_gpt":0.3741671637425735,"score_spread":0.1450050965574408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}