{"id":"W2100532651","doi":"10.1161/circulationaha.110.948570","title":"Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels","year":2011,"lang":"en","type":"review","venue":"Circulation","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":524,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gibson Energy (Canada)","funders":"Institute of Genetics; National Center for Research Resources; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; University of Texas MD Anderson Cancer Center; National Institutes of Health; Terveyden ja hyvinvoinnin laitos; Universität Greifswald; Hjartavernd; U.S. Department of Veterans Affairs; Office of Research and Development; Oulun Yliopisto; Universitair Medisch Centrum Groningen; Rijksuniversiteit Groningen; Universiteit Leiden; King's College London; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; University of Texas Health Science Center at Houston; Imperial College London; University of Washington; Helsingin Yliopisto; Cedars-Sinai Medical Center; National Institute of Diabetes and Digestive and Kidney Diseases; Biocenter, University of Oulu; Consiglio Nazionale delle Ricerche; Amgen; National Cancer Institute; Wake Forest University; Háskóli Íslands; University of Minnesota; British Heart Foundation; University of North Carolina at Chapel Hill; Brigham and Women's Hospital","keywords":"Genome-wide association study; Genetics; Genetic association; Single-nucleotide polymorphism; Medicine; Inflammation; Allele; C-reactive protein; Disease; Biology; Gene; Bioinformatics; Immunology; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01422724,0.002226999,0.005937939,0.004319767,0.0009940587,0.003066726,0.001899317,0.002019716,0.002332314],"category_scores_gemma":[0.01682178,0.001180295,0.02010115,0.007457127,0.000632686,0.0008406899,0.001672961,0.001931099,0.0002974243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000781117,"about_ca_system_score_gemma":0.001004792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006316172,"about_ca_topic_score_gemma":0.009251084,"domain_scores_codex":[0.9873931,0.006921393,0.001399962,0.002780964,0.0009757867,0.0005287939],"domain_scores_gemma":[0.9825032,0.01145284,0.002065087,0.002857873,0.0007305445,0.0003905537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003687737,0.00003613681,0.3881432,0.002150574,0.591548,0.000631778,0.00008203623,0.001982575,0.001689531,0.0002553252,0.001277452,0.008515719],"study_design_scores_gemma":[0.0007910764,0.0004871138,0.3220259,0.0007026939,0.6665081,0.0008272754,0.0001231823,0.004165286,0.0008342963,0.001235396,0.002249397,0.00005017319],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6503485,0.317846,0.01886103,0.002173457,0.0009956347,0.0001718432,0.006859337,0.0008046231,0.001939501],"genre_scores_gemma":[0.9817152,0.0114962,0.003971658,0.0004132818,0.0001785806,0.0001478134,0.00159087,0.0001072912,0.0003790854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01422724,"threshold_uncertainty_score":0.07524174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2291620671851327,"score_gpt":0.3741671637425735,"score_spread":0.1450050965574408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}