{"id":"W2100547283","doi":"10.1152/ajpcell.00056.2006","title":"Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"PCAF; MyoD; MYF5; Myogenin; Biology; Cell biology; Acetyltransferase; Growth factor; Coactivator; Cell growth; Viability assay; Cancer research; P300-CBP Transcription Factors; Myocyte; Cell; Molecular biology; Gene expression; Transcription factor; Gene; Genetics; Acetylation; Receptor; Myogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294098,0.0003246518,0.0002805633,0.0003758119,0.0001798369,0.0004964103,0.0002896995,0.0002472244,0.0005886581],"category_scores_gemma":[0.000307276,0.0001760325,0.0002748333,0.0002497818,0.0002921018,0.0002760879,0.000285049,0.000453426,0.0003675296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004405139,"about_ca_system_score_gemma":0.0002757727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001704814,"about_ca_topic_score_gemma":0.002533119,"domain_scores_codex":[0.9996879,0.00003328025,0.00002351194,0.00005865137,0.0001138258,0.00008289694],"domain_scores_gemma":[0.9998348,0.00002705635,0.00002721721,0.00002169993,0.00003287327,0.00005631793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000175935,0.000009169611,0.0004352901,0.00002044202,0.000005248078,0.00002647921,0.00001106845,0.00001926666,0.9976068,0.0001046562,0.00001791314,0.001567862],"study_design_scores_gemma":[0.0000588917,0.0003522661,0.03842375,0.00001002273,0.00003821645,0.0008273002,0.0000564135,0.001530122,0.955792,0.0002284196,0.002664499,0.00001817229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873208,0.005008273,0.00556365,0.0001075296,0.00002323574,0.0000218873,0.0003124101,0.0001004664,0.001541857],"genre_scores_gemma":[0.9929316,0.001390541,0.003203114,0.00005850345,0.00001594942,0.00004582858,0.000919916,0.00002497609,0.001409549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704814,"threshold_uncertainty_score":0.003389776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006979977224302669,"score_gpt":0.2262592332899076,"score_spread":0.2192792560656049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}