{"id":"W2100554355","doi":"10.1093/cvr/cvu001","title":"Survivin gene therapy attenuates left ventricular systolic dysfunction in doxorubicin cardiomyopathy by reducing apoptosis and fibrosis","year":2014,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Survivin; Apoptosis; Medicine; Doxorubicin; Inhibitor of apoptosis; Internal medicine; Cancer research; TUNEL assay; Cardiomyopathy; Myocyte; Heart failure; Endocrinology; Biology; Programmed cell death; Chemotherapy; Immunohistochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006190665,0.0002808667,0.0009132229,0.0005591369,0.0002535068,0.0001036505,0.0001497794,0.0002981396,0.00001917422],"category_scores_gemma":[0.0003923197,0.0002643925,0.0006758611,0.0008839127,0.0001918365,0.0001568549,0.00008373497,0.000668201,0.00002481022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003436814,"about_ca_system_score_gemma":0.00009459633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001196273,"about_ca_topic_score_gemma":0.000005848953,"domain_scores_codex":[0.9953972,0.001296258,0.0003689195,0.0008277883,0.001398909,0.0007109486],"domain_scores_gemma":[0.9981424,0.0002194344,0.00004622541,0.0009888158,0.0003421935,0.0002608831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001810443,0.00009869873,0.005333867,0.0002496301,0.001206548,0.00002869057,0.0004634732,0.0002596722,0.9186625,0.00002021141,0.0009909226,0.07250471],"study_design_scores_gemma":[0.003904613,0.0003101687,0.009839808,0.0002795043,0.0001579684,0.0002620073,0.0002893201,0.0004139706,0.9648323,0.00005839372,0.01934787,0.0003040408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761156,0.02006098,0.001297082,0.0003500103,0.0001461141,0.001150455,0.000008860893,0.00007434707,0.0007965175],"genre_scores_gemma":[0.9943298,0.004545865,0.0001428868,0.00008591498,0.0004603871,0.0001178405,0.0001004101,0.00007256815,0.0001443433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07220067,"threshold_uncertainty_score":0.9999808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122972596646058,"score_gpt":0.2860470263234597,"score_spread":0.2548173003569992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}