{"id":"W2100578782","doi":"10.1093/nass/nrn203","title":"RNA containing pyrrolocytidine base analogs: good binding affinity and fluorescence that responds to hybridization","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Symposium Series","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University","funders":"","keywords":"Fluorescence; Nucleic acid; RNA; Chemistry; DNA; Substituent; Duplex (building); Nucleoside; Base pair; Biochemistry; Biophysics; Stereochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002121302,0.0003096694,0.0002730236,0.00008450762,0.0004065714,0.00005874764,0.0002765717,0.0002167922,0.00003557534],"category_scores_gemma":[0.000121439,0.0003170299,0.00007650773,0.0002047564,0.0002521283,0.00004055768,0.0003030073,0.000151518,0.00001681042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003943765,"about_ca_system_score_gemma":0.00009755859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001372413,"about_ca_topic_score_gemma":0.000008722468,"domain_scores_codex":[0.9984029,0.00006000963,0.0002689399,0.0006101571,0.0002321648,0.0004258373],"domain_scores_gemma":[0.9990284,0.0000216401,0.0001163533,0.0004729001,0.0001017291,0.0002589696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005673838,0.00003777812,0.01480498,0.00003042479,0.00003708553,0.00004207592,0.0003473422,0.00002158815,0.9826862,0.00008323626,0.001078051,0.0002639145],"study_design_scores_gemma":[0.0006329064,0.0006098047,0.003712726,0.00003870758,0.00002701749,0.0002618771,0.0005517027,0.00004956896,0.9841185,0.00001274979,0.009579724,0.000404674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954213,0.0001667498,0.0003070957,0.0007189243,0.0001461783,0.0001607231,0.00005049923,0.00007695522,0.002951559],"genre_scores_gemma":[0.9954386,0.0005414558,0.001956543,0.0003919198,0.0002239292,0.00002175266,0.00014624,0.00005339944,0.001226096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01109226,"threshold_uncertainty_score":0.9999282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300428773768932,"score_gpt":0.2213960408229133,"score_spread":0.208391753085224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}