{"id":"W2100630326","doi":"10.1200/jco.2012.45.3639","title":"Designing Transformative Clinical Trials in the Cancer Genome Era","year":2013,"lang":"en","type":"review","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"KRAS; Medicine; Clinical trial; Genotyping; Precision medicine; Personalized medicine; Breast cancer; Computational biology; Cancer; Bioinformatics; Colorectal cancer; Internal medicine; Biology; Gene; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":["metaresearch","research_integrity"],"category_scores_codex":[0.0516126,0.0003490251,0.006586966,0.0001236637,0.0000452922,0.00004668714,0.001077634,0.00167272,0.00008612476],"category_scores_gemma":[0.02167416,0.0001923447,0.003439553,0.0001511202,0.0002590987,0.00000840773,0.0001052791,0.002460186,0.00002165691],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001031114,"about_ca_system_score_gemma":0.006313171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002637601,"about_ca_topic_score_gemma":0.0001001939,"domain_scores_codex":[0.9777381,0.01062315,0.01065927,0.0003743061,0.0002588429,0.0003463108],"domain_scores_gemma":[0.975615,0.01600327,0.007432247,0.0003904719,0.0003065203,0.0002524655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002112305,0.000376596,0.00004870576,0.0003256159,0.0006992965,0.00005517006,0.0000511094,0.00001456505,0.000008640693,0.00002249296,0.0088039,0.9893827],"study_design_scores_gemma":[0.001825091,0.003535265,0.0001743696,0.0007741924,0.001276898,0.0001057938,0.00006639358,0.000002121545,0.00000282019,0.0001064475,0.9919133,0.000217314],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004981273,0.993529,0.001019737,0.0007483418,0.002500748,0.0009130741,0.00005964636,0.000001409496,0.0007299609],"genre_scores_gemma":[0.0001677476,0.9888924,0.001975335,0.001950637,0.006810436,0.000086435,0.00003018602,0.0000362229,0.0000505742],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9891654,"threshold_uncertainty_score":0.9998412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4432667977184366,"score_gpt":0.591966524882437,"score_spread":0.1486997271640004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}