{"id":"W2100633524","doi":"10.2337/db09-1105","title":"Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; University of Minnesota","keywords":"Protein Carbonylation; Insulin resistance; Adipose tissue; Endocrinology; Internal medicine; Reactive oxygen species; Adipocyte; Biology; Oxidative stress; Chemistry; Insulin; Biochemistry; Medicine; Lipid peroxidation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931047,0.0005958962,0.0003052232,0.0003796755,0.0002105104,0.0003209552,0.0002372615,0.0003160941,0.001838814],"category_scores_gemma":[0.0001143603,0.0002086239,0.0005018402,0.0003244897,0.0004017774,0.0001824038,0.0002399658,0.0006396339,0.0004704126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003739546,"about_ca_system_score_gemma":0.0002539575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006053717,"about_ca_topic_score_gemma":0.0008056171,"domain_scores_codex":[0.9998436,0.00002090553,0.00001833844,0.0000457065,0.00004293528,0.00002852871],"domain_scores_gemma":[0.9998263,0.00001917761,0.0000799603,0.00001739048,0.0000187726,0.00003842865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001607674,0.00001830332,0.0002679937,0.00002434769,0.00000952685,0.00003055647,0.00000502595,0.0000352166,0.9991109,0.00002528194,0.00001491759,0.0002971278],"study_design_scores_gemma":[0.00004042123,0.0003661531,0.009436807,0.000006515636,0.00005450472,0.0003011703,0.00003767264,0.0007731394,0.9878789,0.00006898656,0.001030397,0.000005339571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947053,0.001019457,0.003187529,0.0001545819,0.00003507312,0.00001867314,0.0003882309,0.0001284155,0.0003628327],"genre_scores_gemma":[0.9924309,0.0009843304,0.002822923,0.00008223217,0.00001096527,0.00004450708,0.0008123713,0.00003818965,0.00277364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001838814,"threshold_uncertainty_score":0.006151438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004095120157323937,"score_gpt":0.2048954805018337,"score_spread":0.2008003603445097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}