{"id":"W2100637998","doi":"10.1161/circresaha.107.157776","title":"Loss of Elastic Fiber Integrity and Reduction of Vascular Smooth Muscle Contraction Resulting From the Upregulated Activities of Matrix Metalloproteinase-2 and -9 in the Thoracic Aortic Aneurysm in Marfan Syndrome","year":2007,"lang":"en","type":"article","venue":"Circulation Research","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; BC Children's Hospital; University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Marfan syndrome; Fibrillin; Thoracic aortic aneurysm; Thoracic aorta; Tissue inhibitor of metalloproteinase; Aortic aneurysm; Downregulation and upregulation; Internal medicine; Aneurysm; Medicine; Aorta; Matrix metalloproteinase; Elastic fiber; Connective tissue; Contraction (grammar); Endocrinology; Cardiology; Pathology; Anatomy; Biology; Surgery; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183938,0.0004126638,0.0002724649,0.0004676808,0.0001570439,0.0001764057,0.00011833,0.0004502576,0.0006785564],"category_scores_gemma":[0.0001486228,0.0003154956,0.0003513006,0.0001186578,0.0002760036,0.0001720452,0.0001807678,0.000565025,0.0001895771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000137897,"about_ca_system_score_gemma":0.0001000117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002808098,"about_ca_topic_score_gemma":0.0003332988,"domain_scores_codex":[0.9998847,0.00002042553,0.0000122178,0.00003241361,0.00002695365,0.00002323235],"domain_scores_gemma":[0.9997874,0.00001815563,0.00008349823,0.00001003491,0.00001157548,0.0000893298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003268415,0.00004438091,0.002736525,0.00001747968,0.0000069576,0.0004823732,0.00003356453,0.000016484,0.9956468,0.00001627992,0.00001166017,0.0006605961],"study_design_scores_gemma":[0.0001068491,0.003021031,0.4145036,0.00002009804,0.00009480899,0.01666779,0.000145277,0.0007940273,0.5633669,0.0001175238,0.00114067,0.0000213927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991621,0.0002991071,0.0003505415,0.00001402996,0.000004685477,0.000004908605,0.0000623723,0.00001576032,0.0000864922],"genre_scores_gemma":[0.997829,0.0004166682,0.0009020269,0.00002575917,0.00001117436,0.00001949231,0.0001985035,0.000009177936,0.0005882428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006785564,"threshold_uncertainty_score":0.002270043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03626743631236639,"score_gpt":0.362814995544548,"score_spread":0.3265475592321817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}