{"id":"W2100721190","doi":"10.1371/journal.pone.0094661","title":"Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1406,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; McGill University and Génome Québec Innovation Centre; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Instituto de Salud Carlos III; Menzies Centre for Australian Studies, King's College London, University of London; University of California, San Francisco; University of California, Davis; National Institutes of Health; Heinz Nixdorf Stiftung; Hjartavernd; H. Lundbeck A/S; Karl-Franzens-Universität Graz; University of Pennsylvania; Austrian Science Fund; Medizinische Universität Graz; Internationale Stichting Alzheimer Onderzoek; National Institute of Child Health and Human Development; Hersenstichting; Medical Research Council; Swedish Brain Power; National Institute of Neurological Disorders and Stroke; Llywodraeth Cymru; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Heart, Lung, and Blood Institute; North Bristol NHS Trust; Vetenskapsrådet; University of Pittsburgh; Stockholms Läns Landsting; Marcus och Amalia Wallenbergs minnesfond; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Karolinska Institutet; ZonMw; Agence Nationale de la Recherche; School of Medicine, Boston University; European Commission; Centro de Biología Molecular Severo Ochoa; Cardiff University; Alzheimer's Research Trust; University of California, Irvine; University College London Hospitals NHS Foundation Trust; University of California, Los Angeles; University of Washington; University of California, San Diego; Johns Hopkins University; National Institute on Deafness and Other Communication Disorders; Rush University; University of Miami; York University; Northwestern University; Ministero della Salute; Alzheimer's Society; National Eye Institute; National Institute for Health and Care Research; Alzheimer Society; Newcastle University; Vanderbilt University; Wellcome Trust; University of Southern California; Massachusetts General Hospital; Emory University; Juvenile Diabetes Research Foundation International","keywords":"Genetics; Biology; Gene; Genome-wide association study; Disease; Alzheimer's disease; Dementia; Genome; Genetic association; Genotype; Single-nucleotide polymorphism; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008258173,0.0003764394,0.0005651871,0.00108697,0.0003794542,0.000779512,0.0005043311,0.0006004637,0.001807133],"category_scores_gemma":[0.002170867,0.0001796328,0.0005875292,0.00106764,0.0004872867,0.0001728639,0.0006224761,0.000749973,0.0002026058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001545246,"about_ca_system_score_gemma":0.0002064018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000687593,"about_ca_topic_score_gemma":0.001115479,"domain_scores_codex":[0.999321,0.0001126771,0.00004373514,0.0003345941,0.00009705019,0.00009092587],"domain_scores_gemma":[0.9985223,0.000808599,0.0003360538,0.0001040227,0.00008541822,0.0001435885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001300612,0.0001239314,0.9123381,0.0000980902,0.0008488113,0.0008118492,0.0001557388,0.0005236584,0.06640574,0.0002700136,0.000485475,0.01663788],"study_design_scores_gemma":[0.00006532502,0.0002133143,0.9907408,0.000006775055,0.0005128427,0.001690015,0.00008440491,0.0008021158,0.004537332,0.0004808362,0.000854464,0.00001178588],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974055,0.0003419152,0.001108368,0.00006433226,0.000007143925,0.000007981635,0.0006959532,0.0000318802,0.0003369233],"genre_scores_gemma":[0.9975821,0.00008155276,0.00132891,0.00005764159,0.00001224772,0.00001325569,0.0007982303,0.000007111614,0.000118929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001807133,"threshold_uncertainty_score":0.006045401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07663922428977946,"score_gpt":0.3201184234940226,"score_spread":0.2434791992042432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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