{"id":"W2100723895","doi":"10.1126/scitranslmed.3000677","title":"Metabolic Modulation of Glioblastoma with Dichloroacetate","year":2010,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":715,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Cancer research; Mitochondrion; Glycolysis; Biology; In vivo; Angiogenesis; Stem cell; Pharmacology; Medicine; Endocrinology; Biochemistry; Cell biology; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009783269,0.0002533174,0.0002218143,0.0002411682,0.0001122503,0.0002331803,0.0001419596,0.0001231523,0.0003879415],"category_scores_gemma":[0.000112288,0.00009171876,0.0001699419,0.0002255647,0.0001387808,0.000104376,0.000143849,0.0002388296,0.0001081495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004433026,"about_ca_system_score_gemma":0.000349725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002590458,"about_ca_topic_score_gemma":0.004642262,"domain_scores_codex":[0.9999269,0.00001714063,0.000006573392,0.00001209743,0.00001266342,0.00002463026],"domain_scores_gemma":[0.9999591,0.000004666614,0.00001322702,0.000005401027,0.000007286795,0.00001036911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001023217,0.0002249227,0.001833527,0.00009041405,0.00002722087,0.0001712347,0.00003759215,0.0003920321,0.9773491,0.0001751218,0.0001552131,0.01852043],"study_design_scores_gemma":[0.0001559178,0.003423704,0.0132481,0.00001137032,0.00007348007,0.0008856768,0.00004418268,0.001003423,0.9760065,0.00008426991,0.005054179,0.000009109876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948766,0.002845951,0.000682736,0.00009498501,0.00002472912,0.00004064991,0.0001425338,0.000031133,0.00126055],"genre_scores_gemma":[0.997694,0.001267572,0.0004723677,0.0000444022,0.000008427997,0.00002517177,0.0001563675,0.000006205521,0.0003255514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002590458,"threshold_uncertainty_score":0.005150795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007662281005010946,"score_gpt":0.2583067019672167,"score_spread":0.2506444209622058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}