{"id":"W2100796422","doi":"10.1016/j.molcel.2009.06.013","title":"FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST","year":2009,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Dephosphorylation; Phosphorylation; Biology; Cell biology; MAPK/ERK pathway; Tyrosine phosphorylation; Cancer research; PIN1; Focal adhesion; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; PAK1; Biochemistry; Phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002689844,0.0002882812,0.000429316,0.0001749884,0.00007324882,0.00003358565,0.0001409098,0.000251704,0.000197596],"category_scores_gemma":[0.0001921977,0.0002838204,0.0001036253,0.0004977763,0.00008533779,0.00007891245,0.00005602613,0.0003182963,0.0000567271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009706338,"about_ca_system_score_gemma":0.0001165782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000104342,"about_ca_topic_score_gemma":0.00000169892,"domain_scores_codex":[0.9976951,0.0001073847,0.0004881503,0.0005207641,0.0007825212,0.0004060392],"domain_scores_gemma":[0.9987416,0.00007580511,0.0001907094,0.0004568115,0.0002326228,0.0003024893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002137843,0.0003480003,0.001202519,0.00007180722,0.00002628121,0.00004647621,0.00009639392,0.000005128071,0.9811311,0.00001949868,0.00712416,0.009714823],"study_design_scores_gemma":[0.002396891,0.0007245112,0.006711505,0.00005448475,0.00007688113,0.000009007417,0.00003375387,0.0009559689,0.9830029,0.00004871099,0.005739708,0.0002456917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982622,0.007047262,0.00261962,0.0008638784,0.00004973758,0.0008629154,0.00002546296,0.0000786142,0.005830471],"genre_scores_gemma":[0.9958584,0.0004079714,0.001155131,0.0005367206,0.00001850347,0.00001270951,0.000600383,0.00005204051,0.001358101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0132364,"threshold_uncertainty_score":0.9999614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008087759439446264,"score_gpt":0.2522479728505022,"score_spread":0.244160213411056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}