{"id":"W2100823111","doi":"10.1373/clinchem.2013.215236","title":"False Biomarker Discovery due to Reactivity of a Commercial ELISA for CUZD1 with Cancer Antigen CA125","year":2013,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Biomarker; Biomarker discovery; Antigen; Cancer; Medicine; Immunology; Chemistry; Internal medicine; Proteomics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.01245446,0.001385296,0.0009200493,0.00213126,0.0007044188,0.00175436,0.001148226,0.001433807,0.001008746],"category_scores_gemma":[0.01794758,0.0007127319,0.0006910135,0.001410711,0.0014893,0.0005368142,0.0009864607,0.001224768,0.0005601608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001315955,"about_ca_system_score_gemma":0.0004939371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149983,"about_ca_topic_score_gemma":0.001127314,"domain_scores_codex":[0.9807042,0.005077884,0.001607074,0.003325013,0.008428524,0.0008571909],"domain_scores_gemma":[0.9876509,0.006953672,0.002011228,0.001296283,0.001752029,0.0003359069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002164902,0.0005012333,0.2570954,0.0009527212,0.0006713131,0.001186594,0.0006409139,0.001552356,0.6946505,0.001000905,0.001675265,0.03790802],"study_design_scores_gemma":[0.00006466425,0.001166234,0.09329201,0.0001065817,0.0004491586,0.004277006,0.0002304432,0.01718928,0.8759494,0.0007682055,0.006456926,0.00005018668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9336298,0.005643757,0.05456293,0.0008951304,0.0003597886,0.0003039865,0.0005958031,0.000805039,0.00320373],"genre_scores_gemma":[0.972087,0.0005971045,0.02448631,0.000870058,0.00005639931,0.0001383685,0.0007711846,0.00005711558,0.0009364417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9985662,"threshold_uncertainty_score":0.06586629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1038942117330637,"score_gpt":0.4580897749634593,"score_spread":0.3541955632303956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}