{"id":"W2100832844","doi":"10.1261/rna.131306","title":"Two independently selected capping ribozymes share similar substrate requirements","year":2006,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Biology; Ribozyme; Substrate (aquarium); Substrate specificity; Computational biology; Ligase ribozyme; RNA; Biochemistry; Enzyme; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442332,0.0001669507,0.0001266267,0.00003619524,0.0001084742,0.00004608098,0.0002030762,0.0001295747,0.0001239142],"category_scores_gemma":[0.00003211575,0.0001657051,0.00006528123,0.0001084435,0.00002050601,0.000005992538,0.00005855505,0.00006760631,0.00004441948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001562333,"about_ca_system_score_gemma":0.00005434969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062584,"about_ca_topic_score_gemma":0.0001233607,"domain_scores_codex":[0.9989152,0.00006036698,0.0002042361,0.0003325845,0.0001790231,0.0003086232],"domain_scores_gemma":[0.9994827,0.000004602494,0.00009025797,0.000273919,0.00009173124,0.000056789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002738076,0.00003056339,0.001447137,0.00001126127,0.00003239615,0.00001079313,0.000007481447,0.0000368613,0.996192,0.000218216,0.001066063,0.0009198689],"study_design_scores_gemma":[0.0003594167,0.0000683438,0.002738723,0.00002358764,0.0000153306,0.000008753293,0.00001976111,0.0000241533,0.9903083,0.0007236954,0.005494444,0.0002154982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98831,0.0008545092,0.001118175,0.00008551819,0.0001270822,0.0002051527,0.00003137354,0.0000369343,0.009231246],"genre_scores_gemma":[0.9970714,0.00003693195,0.0007084757,0.0001303624,0.0003294988,0.00002621403,0.0002262341,0.00002807829,0.001442785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008761411,"threshold_uncertainty_score":0.6757259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528408265849971,"score_gpt":0.2499249535059092,"score_spread":0.2346408708474094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}