{"id":"W2100832844","doi":"10.1261/rna.131306","title":"Two independently selected capping ribozymes share similar substrate requirements","year":2006,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Biology; Ribozyme; Substrate (aquarium); Substrate specificity; Computational biology; Ligase ribozyme; RNA; Biochemistry; Enzyme; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000568311,0.00066813,0.0006600054,0.0002435287,0.0001175623,0.0006978129,0.0004457943,0.0004446245,0.0004950112],"category_scores_gemma":[0.0007355508,0.0002213212,0.0003880988,0.0002332584,0.0002799709,0.000232087,0.0002579634,0.0006559829,0.0004354373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001943751,"about_ca_system_score_gemma":0.0001076854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006674586,"about_ca_topic_score_gemma":0.00009328949,"domain_scores_codex":[0.9994491,0.0001067204,0.00004576919,0.0001265305,0.0001979802,0.00007394035],"domain_scores_gemma":[0.9994922,0.0001647535,0.0001146764,0.00006332796,0.00006391791,0.000101209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005603223,0.00001910348,0.0003915082,0.00002178322,0.000005595717,0.00007932654,0.00001336478,0.0001892322,0.99683,0.0001266443,0.00001327805,0.002253962],"study_design_scores_gemma":[0.000008626295,0.0002044291,0.001104627,0.000002352606,0.00001554062,0.0006830159,0.000009416518,0.001265918,0.9953993,0.00006727189,0.001234289,0.000005246432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705978,0.001416952,0.02530997,0.00004628359,0.00004562033,0.00008421767,0.0001340838,0.0001419022,0.00222312],"genre_scores_gemma":[0.9691522,0.0004473179,0.02691504,0.00008544714,0.00002812665,0.00007868892,0.001556273,0.00008316455,0.00165384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006978129,"threshold_uncertainty_score":0.003005564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528408265849971,"score_gpt":0.2499249535059092,"score_spread":0.2346408708474094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}