{"id":"W2100843807","doi":"10.1002/humu.22262","title":"Cancer Risks for<i>MLH</i><i>1</i>and<i>MSH</i><i>2</i>Mutation Carriers","year":2012,"lang":"he","type":"article","venue":"Human Mutation","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"National Cancer Institute","keywords":"MLH1; MSH2; Biology; Colorectal cancer; Cancer; Mutation; Lifetime risk; Cumulative risk; Lynch syndrome; Internal medicine; Genetics; Oncology; Medicine; Gene; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007923337,0.0005347001,0.000592685,0.0002583958,0.0005790551,0.0001036718,0.0001496796,0.0004331175,0.00101693],"category_scores_gemma":[0.0003059611,0.0005628348,0.000194517,0.000337834,0.0003073608,0.0004171966,0.00006844682,0.0004273999,0.000105632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007476741,"about_ca_system_score_gemma":0.0003210175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009351835,"about_ca_topic_score_gemma":0.0004034806,"domain_scores_codex":[0.9966999,0.0001806319,0.0007709436,0.0006524113,0.0006573005,0.001038848],"domain_scores_gemma":[0.9978004,0.0003065105,0.0004745025,0.0004027212,0.0004441211,0.0005718195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002677632,0.001121525,0.3536614,0.006649941,0.002501379,0.00006502603,0.1194219,0.002146297,0.1423716,0.006523793,0.0567744,0.3060851],"study_design_scores_gemma":[0.02210149,0.004326296,0.7263734,0.001887138,0.007289593,0.0003220919,0.01097203,0.004322062,0.1223142,0.006043389,0.09037004,0.003678291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713711,0.01693759,0.001831149,0.0006067679,0.00425903,0.002363214,0.000213921,0.0001328885,0.002284306],"genre_scores_gemma":[0.991718,0.0004999603,0.001320377,0.001023672,0.002738442,0.0007048896,0.0003508983,0.0001487574,0.001494986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3727119,"threshold_uncertainty_score":0.9998963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0765710816633613,"score_gpt":0.3827316781193149,"score_spread":0.3061605964559536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}