{"id":"W2100843807","doi":"10.1002/humu.22262","title":"Cancer Risks for<i>MLH</i><i>1</i>and<i>MSH</i><i>2</i>Mutation Carriers","year":2012,"lang":"he","type":"article","venue":"Human Mutation","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"National Cancer Institute","keywords":"MLH1; MSH2; Biology; Colorectal cancer; Cancer; Mutation; Lifetime risk; Cumulative risk; Lynch syndrome; Internal medicine; Genetics; Oncology; Medicine; Gene; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008972492,0.0003429577,0.0003788387,0.001029453,0.0003799041,0.0002960508,0.000241593,0.0004126531,0.001163544],"category_scores_gemma":[0.003743718,0.0003657999,0.0004889751,0.0007791927,0.0003001347,0.0002452862,0.0003280847,0.0003217646,0.0001772602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003502596,"about_ca_system_score_gemma":0.0001978372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01014442,"about_ca_topic_score_gemma":0.007623872,"domain_scores_codex":[0.9993462,0.0002318668,0.00005856364,0.0001901217,0.00008538945,0.00008777646],"domain_scores_gemma":[0.9981924,0.0005733888,0.0007105502,0.0002345485,0.00009423406,0.0001950013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002206542,0.0000119855,0.9972089,0.000004715435,0.00008692626,0.0001556561,0.00009355034,0.0001345225,0.0004549609,0.00002729562,0.00004820522,0.001552518],"study_design_scores_gemma":[0.00002450103,0.0002291477,0.9975435,0.000003773578,0.0001046404,0.0008802026,0.0001101073,0.0004367051,0.0003276922,0.00007236196,0.0002589682,0.000008322399],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995511,0.00009350647,0.00009690872,0.000007861499,8.58942e-7,0.000002891491,0.0001683619,0.000002584826,0.00007585213],"genre_scores_gemma":[0.9991472,0.00006698527,0.0001817326,0.000007293116,0.000004137815,0.000006746889,0.0004285808,0.000002381749,0.0001550097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01014442,"threshold_uncertainty_score":0.02017075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0765710816633613,"score_gpt":0.3827316781193149,"score_spread":0.3061605964559536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}