{"id":"W2100877880","doi":"10.1371/journal.pone.0112714","title":"Deletion of Apoptosis Signal-Regulating Kinase 1 (ASK1) Protects Pancreatic Beta-Cells from Stress-Induced Death but Not from Glucose Homeostasis Alterations under Pro-Inflammatory Conditions","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Servier","keywords":"ASK1; Beta cell; Pancreatic islets; Glucose homeostasis; Internal medicine; Endocrinology; Apoptosis; Programmed cell death; Downregulation and upregulation; Proinflammatory cytokine; Inflammation; Biology; Kinase; Insulin; Protein kinase A; Insulin resistance; Cell biology; Islet; Medicine; Mitogen-activated protein kinase kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963205,0.0005921808,0.0003265385,0.0002440722,0.0001645503,0.0004131743,0.0003004582,0.0003085068,0.002675112],"category_scores_gemma":[0.0001880581,0.0001356642,0.000302556,0.0001787239,0.0003599504,0.0005283731,0.0003114138,0.0007830361,0.0005138788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776989,"about_ca_system_score_gemma":0.0001948107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000662537,"about_ca_topic_score_gemma":0.00008721693,"domain_scores_codex":[0.9998479,0.00002203995,0.00003224826,0.00004063137,0.00002896914,0.00002817023],"domain_scores_gemma":[0.9996978,0.00004991169,0.0001172473,0.00003272508,0.00002874119,0.00007356938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003387378,0.00003694192,0.0003847638,0.0000965784,0.00000835945,0.00003922017,0.00001859524,0.00003806809,0.997986,0.00006588513,0.00002261913,0.0009643189],"study_design_scores_gemma":[0.00002407752,0.0003586093,0.003798025,0.000009593391,0.00003192024,0.0002374642,0.00003800681,0.0003317785,0.994077,0.00004945633,0.001039027,0.000005032307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942378,0.001354753,0.003224113,0.0001192819,0.00004316381,0.00002216699,0.0004624166,0.00007006552,0.0004662534],"genre_scores_gemma":[0.9937132,0.001207632,0.002339146,0.00006839121,0.00002023085,0.0000523065,0.0009831709,0.00002849099,0.001587322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002675112,"threshold_uncertainty_score":0.008949161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04708054038214324,"score_gpt":0.2423113698332251,"score_spread":0.1952308294510819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}