{"id":"W2100886241","doi":"10.1128/aac.01216-09","title":"Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"NS5B; Polymerase; Biology; RNA polymerase; RNA; Nucleotide; RNA-dependent RNA polymerase; Pyrophosphate; Mutation; Molecular biology; Biochemistry; Virus; Enzyme; Virology; Hepatitis C virus; Gene; Hepacivirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003089286,0.0004928046,0.000390766,0.0001984198,0.0001283179,0.0003281335,0.0004163708,0.0004493231,0.0009484288],"category_scores_gemma":[0.000191405,0.0002133606,0.0003867641,0.00008537434,0.0002858001,0.0002926507,0.0001543308,0.0003794229,0.0004335465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003043149,"about_ca_system_score_gemma":0.0001430776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002394146,"about_ca_topic_score_gemma":0.0001828141,"domain_scores_codex":[0.9998153,0.00004651639,0.00001159606,0.00003511188,0.0000528685,0.00003860215],"domain_scores_gemma":[0.9998542,0.00004958159,0.00004771868,0.0000132163,0.00001934682,0.00001597641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001469696,0.00003221806,0.0002628826,0.0000994168,0.00001283344,0.0001075391,0.00001487477,0.0003475526,0.9960444,0.0003234803,0.00003208597,0.002575804],"study_design_scores_gemma":[0.0000241865,0.0006879427,0.001464273,0.000005894542,0.00001494929,0.0004529327,0.000009721813,0.001646317,0.9943371,0.00008506742,0.001265026,0.000006617553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620574,0.01730474,0.01407495,0.0002182351,0.00007129317,0.0002027228,0.0004216368,0.0002421594,0.005406844],"genre_scores_gemma":[0.9946092,0.002203505,0.001878027,0.00005997576,0.00002056004,0.00004528179,0.0001524056,0.00001071734,0.001020282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009484288,"threshold_uncertainty_score":0.003172815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01417964604804012,"score_gpt":0.2716019127980204,"score_spread":0.2574222667499803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}