{"id":"W2100892027","doi":"10.1371/journal.pone.0097518","title":"Human Motor Neurons Generated from Neural Stem Cells Delay Clinical Onset and Prolong Life in ALS Mouse Model","year":2014,"lang":"nl","type":"article","venue":"PLoS ONE","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital","funders":"National Institutes of Health; University of British Columbia; National Science Council","keywords":"OLIG2; Motor neuron; Sonic hedgehog; Amyotrophic lateral sclerosis; Spinal cord; Neural stem cell; Transplantation; Medicine; Choline acetyltransferase; Neuroscience; Biology; Pathology; Stem cell; Central nervous system; Internal medicine; Disease; Oligodendrocyte; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515729,0.0005148094,0.0004080567,0.0002566639,0.0001380589,0.0001999042,0.0002480032,0.0004525753,0.001633033],"category_scores_gemma":[0.00008441769,0.000133074,0.0002352109,0.0001049167,0.0002282332,0.0002308919,0.0001629125,0.0009062414,0.0004617071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777172,"about_ca_system_score_gemma":0.0002214721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004508129,"about_ca_topic_score_gemma":0.0009852444,"domain_scores_codex":[0.99986,0.00001294277,0.00001733196,0.00003503357,0.00004724968,0.00002750194],"domain_scores_gemma":[0.9999261,0.000007126884,0.00001963488,0.000008898246,0.00001027854,0.00002790945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002451574,0.0001210153,0.0001917644,0.00007167276,0.00001054043,0.00008126469,0.000031584,0.00007759687,0.9959571,0.000120209,0.0001878221,0.002904285],"study_design_scores_gemma":[0.00008527928,0.002249334,0.003171036,0.00002406587,0.00006225792,0.0005393904,0.00004119143,0.0009893182,0.9851317,0.000131926,0.007566387,0.00000818018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828818,0.004856176,0.007909947,0.0003388712,0.0002176355,0.0001245293,0.0007316771,0.0005132951,0.002426118],"genre_scores_gemma":[0.9800396,0.00340993,0.003810515,0.000161417,0.00003715392,0.0002211702,0.001218175,0.00005209891,0.01104989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633033,"threshold_uncertainty_score":0.005463004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1578492860520604,"score_gpt":0.3249383467762246,"score_spread":0.1670890607241642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}