{"id":"W2100912366","doi":"10.1016/j.joca.2010.09.002","title":"Endoglin differentially regulates TGF-β-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes","year":2010,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University","funders":"National Institute on Aging; Canadian Institutes of Health Research; Jewish General Hospital; Maine Medical Center Research Institute; University of Tokyo; McGill University","keywords":"Endoglin; SMAD; Chondrocyte; Cell biology; Chemistry; Gene knockdown; Extracellular matrix; Transforming growth factor; Cartilage; Phosphorylation; Receptor; Signal transduction; Biology; Biochemistry; Anatomy; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409143,0.0002610998,0.0002320771,0.00008063043,0.0002238685,0.0001434208,0.00005789993,0.0001709386,0.00001296451],"category_scores_gemma":[0.00004473726,0.0002394089,0.00002468986,0.00004953416,0.0001123044,0.00003384894,0.00009916708,0.0001863418,3.861303e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004171097,"about_ca_system_score_gemma":0.0000181754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008314611,"about_ca_topic_score_gemma":0.0002957045,"domain_scores_codex":[0.9986387,0.00007615097,0.0002755454,0.0006070554,0.000141878,0.00026063],"domain_scores_gemma":[0.9994723,0.0000192242,0.0001272855,0.000177397,0.00005947593,0.0001443488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001008164,0.00004736899,0.01178709,0.00008974754,0.000005856529,0.00001545526,0.0003077837,0.000009218948,0.9861546,0.00002149061,0.000003095118,0.001457512],"study_design_scores_gemma":[0.001217083,0.0003920703,0.005266584,0.0002158033,0.00003651868,0.00003941404,0.00009943396,0.00006027718,0.9922107,0.0001117142,0.0000532741,0.00029706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831454,0.01626542,0.00005068312,0.00001747236,0.0000957487,0.0003785913,0.00001565763,0.00002354433,0.000007507903],"genre_scores_gemma":[0.9990052,0.0003387493,0.0001101539,0.000004686342,0.00009680627,0.00003975688,0.0001104999,0.00003726427,0.0002568745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01592667,"threshold_uncertainty_score":0.9762813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005532099143448691,"score_gpt":0.2063249046372422,"score_spread":0.2007928054937935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}