{"id":"W2100915153","doi":"10.1073/pnas.1100869108","title":"T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Celator Pharmaceuticals (Canada); University of British Columbia","funders":"Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Irritable bowel syndrome; Visceral pain; Medicine; Nociception; Butyrate; Voltage-dependent calcium channel; Calcium channel; Abdominal pain; Chronic pain; Hyperalgesia; T-type calcium channel; L-type calcium channel; Neuropathic pain; Pathophysiology; Calcium; Internal medicine; Pharmacology; Endocrinology; Receptor; Chemistry; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004687099,0.0009872359,0.0009788111,0.0008871141,0.0003936326,0.0003986081,0.0004255488,0.00107354,0.003806236],"category_scores_gemma":[0.000549749,0.0004954209,0.000883417,0.0004180287,0.0009316382,0.0006914476,0.0003140847,0.00271644,0.0007324615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000601751,"about_ca_system_score_gemma":0.0006640843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160173,"about_ca_topic_score_gemma":0.001967209,"domain_scores_codex":[0.9996209,0.00008642668,0.00003099665,0.00005228721,0.00007260594,0.0001367973],"domain_scores_gemma":[0.9993877,0.00008052621,0.0001499442,0.00007666781,0.00006080588,0.0002442612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002979997,0.000555977,0.0002183036,0.00008671427,0.00001966419,0.0002410986,0.0000340816,0.0001425576,0.9939547,0.0001316915,0.0001352501,0.0015],"study_design_scores_gemma":[0.001918161,0.01657404,0.01118634,0.0001049316,0.000190205,0.001624465,0.0002468782,0.004963358,0.9596361,0.0006848519,0.002813269,0.00005733746],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931741,0.001563587,0.002491719,0.0007340133,0.0001948398,0.0001245596,0.0003152302,0.0001652852,0.001236617],"genre_scores_gemma":[0.9907237,0.002195253,0.002196796,0.0003558211,0.00007987698,0.0002706315,0.0004798581,0.00005751595,0.003640494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003806236,"threshold_uncertainty_score":0.0127331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09798876197385058,"score_gpt":0.319696527298735,"score_spread":0.2217077653248844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}