{"id":"W2100922770","doi":"10.1002/mus.20291","title":"Molecular clues into the pathogenesis of statin‐mediated muscle toxicity","year":2005,"lang":"en","type":"review","venue":"Muscle & Nerve","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Myopathy; Prenylation; Statin; Skeletal muscle; myalgia; Biology; Rhabdomyolysis; Pathogenesis; Creatine kinase; Internal medicine; Endocrinology; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004250467,0.0009969444,0.001263423,0.001847849,0.0003079676,0.00100705,0.001249289,0.001503382,0.004277376],"category_scores_gemma":[0.000409653,0.0002630218,0.0003991239,0.00141307,0.0006266339,0.001585788,0.0005785531,0.001778126,0.004330098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007749533,"about_ca_system_score_gemma":0.0008207447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007498372,"about_ca_topic_score_gemma":0.001069969,"domain_scores_codex":[0.9999001,0.0000181788,0.00001472486,0.00001864756,0.00003559742,0.00001258706],"domain_scores_gemma":[0.9998858,0.00003827877,0.00001463993,0.000007202534,0.00003717285,0.00001685978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001910092,0.0001314227,0.0003714581,0.01179116,0.0001160989,0.001837,0.0001274108,0.0007823174,0.0157347,0.01246076,0.03970455,0.9167522],"study_design_scores_gemma":[0.00004021955,0.0001021617,0.001200105,0.00238572,0.00009065568,0.003696969,0.0001152931,0.0001943591,0.002338694,0.008024468,0.9817824,0.00002897717],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002330837,0.9972077,0.0003362189,0.00045485,0.0002599902,0.000004316648,0.00001726277,0.00001542157,0.001471152],"genre_scores_gemma":[0.001083642,0.9972534,0.0003303102,0.0001995219,0.0001429061,0.00000571622,0.00002704482,0.000001416395,0.0009560825],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004277376,"threshold_uncertainty_score":0.01430923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893563775480985,"score_gpt":0.2968020590728967,"score_spread":0.2778664213180869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}