{"id":"W2100946220","doi":"10.1128/aac.49.4.1441-1446.2005","title":"Topoisomerase I Amino Acid Substitutions, Gly185Arg and Asp325Glu, Confer Camptothecin Resistance in <i>Leishmania donovani</i>","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University Health Centre","funders":"Centre Hospitalier Universitaire de Québec","keywords":"Camptothecin; Topoisomerase; Biology; Gene; Mutagenesis; Amino acid; Leishmania donovani; Genetics; Mutation; Mechanism of action; DNA; Molecular biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001027615,0.0002075443,0.000192567,0.00004814296,0.0001045408,0.00006031718,0.0001098287,0.0001383873,0.00005683533],"category_scores_gemma":[0.000002916471,0.0002027955,0.00004739188,0.00007251262,0.0001039745,0.00001241793,0.00004352866,0.0000900774,0.000004548639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002133374,"about_ca_system_score_gemma":0.00003987736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000551977,"about_ca_topic_score_gemma":0.000963983,"domain_scores_codex":[0.9989992,0.00002216118,0.000217931,0.0004103357,0.00007228579,0.0002780631],"domain_scores_gemma":[0.999601,0.000003866847,0.00006402176,0.0002178336,0.00003391315,0.0000793739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003336337,0.0001804671,0.003296657,0.00002933168,0.00006761961,0.000006406348,0.0002914499,0.000002297182,0.9661371,0.001213624,0.009192657,0.01924879],"study_design_scores_gemma":[0.002200389,0.000066818,0.005487685,0.0000299619,0.00001117342,0.00001607691,0.00002574458,0.00001342421,0.3784608,0.00009754837,0.6133199,0.0002703864],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947214,0.001207757,0.0003903509,0.00271425,0.0001044418,0.0002211229,0.0000393577,0.00001190606,0.0005894228],"genre_scores_gemma":[0.9730108,0.009404549,0.001152122,0.01485137,0.0002177445,0.00001045205,0.00004691151,0.0000293309,0.001276668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6041273,"threshold_uncertainty_score":0.8269762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00829745223738876,"score_gpt":0.235988341017456,"score_spread":0.2276908887800672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}