{"id":"W2100946220","doi":"10.1128/aac.49.4.1441-1446.2005","title":"Topoisomerase I Amino Acid Substitutions, Gly185Arg and Asp325Glu, Confer Camptothecin Resistance in <i>Leishmania donovani</i>","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University Health Centre","funders":"Centre Hospitalier Universitaire de Québec","keywords":"Camptothecin; Topoisomerase; Biology; Gene; Mutagenesis; Amino acid; Leishmania donovani; Genetics; Mutation; Mechanism of action; DNA; Molecular biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008764664,0.0003315721,0.0002406399,0.0001419164,0.0001173537,0.0002057359,0.0001903668,0.0002084104,0.000601792],"category_scores_gemma":[0.000103272,0.000158249,0.0002332481,0.0001211537,0.0001951255,0.00007860442,0.0002193287,0.0004150128,0.0002862891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002925536,"about_ca_system_score_gemma":0.0001927179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007837557,"about_ca_topic_score_gemma":0.001206197,"domain_scores_codex":[0.9999028,0.00002041264,0.00001236555,0.00002108621,0.0000227546,0.00002042806],"domain_scores_gemma":[0.9999226,0.0000136331,0.00003100083,0.0000092953,0.000006490205,0.0000169448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004050534,0.00001394129,0.0002530818,0.0000188034,0.000003797712,0.0000844496,0.000008204177,0.00003141532,0.9991381,0.00003042622,0.00001318416,0.0003641204],"study_design_scores_gemma":[0.00001874591,0.0002576524,0.006600879,0.000006786392,0.00002666949,0.001164839,0.00004667804,0.0006111826,0.9893152,0.0000257026,0.001919191,0.000006582227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984622,0.0002259173,0.0005910408,0.00003985266,0.000009541498,0.00001661991,0.000196708,0.00002281733,0.0004354109],"genre_scores_gemma":[0.9966496,0.0002493267,0.001428206,0.0000417898,0.000005794195,0.00001632487,0.0007121543,0.00002626556,0.000870474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007837557,"threshold_uncertainty_score":0.002122641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00829745223738876,"score_gpt":0.235988341017456,"score_spread":0.2276908887800672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}