{"id":"W2100960809","doi":"10.1126/scitranslmed.3005688","title":"A Preclinical Xenograft Model Identifies Castration-Tolerant Cancer-Repopulating Cells in Localized Prostate Tumors","year":2013,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Prostate cancer; Medicine; Cancer research; Castration; Stromal cell; Prostate; Cancer; Androgen deprivation therapy; Oncology; Internal medicine; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003883101,0.0007415928,0.0005588213,0.0007956671,0.0003058807,0.0004727345,0.0006365505,0.0006181075,0.003466891],"category_scores_gemma":[0.0001661677,0.0003711186,0.000503223,0.0004057136,0.0003923429,0.000579551,0.0003009017,0.001876105,0.001073869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004089885,"about_ca_system_score_gemma":0.0005233021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001360834,"about_ca_topic_score_gemma":0.002796396,"domain_scores_codex":[0.9997446,0.00004858204,0.00002017505,0.000061991,0.00006648755,0.00005818003],"domain_scores_gemma":[0.9997085,0.00005042251,0.00005058483,0.00005526292,0.00002408644,0.0001111928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000504841,0.0007030335,0.0003845156,0.00009067582,0.0000153314,0.000222915,0.00005797455,0.0004495807,0.9934187,0.0008143771,0.0005135296,0.002824562],"study_design_scores_gemma":[0.0002297308,0.007343338,0.004475917,0.00003308841,0.00005952609,0.00133303,0.00008874057,0.004472091,0.9730886,0.0003104504,0.008542232,0.00002343073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439499,0.004663921,0.03594453,0.000566459,0.0004619583,0.0006526058,0.003514231,0.001297899,0.008948672],"genre_scores_gemma":[0.965789,0.002493413,0.01627609,0.0001325693,0.00005862656,0.0003469495,0.002927902,0.0001433697,0.01183217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003466891,"threshold_uncertainty_score":0.01159793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0774734027286277,"score_gpt":0.4059545803426766,"score_spread":0.3284811776140489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}