{"id":"W2100970263","doi":"10.1158/0008-5472.can-04-2446","title":"Increased Insulin-Like Growth Factor I Receptor Expression and Signaling Are Components of Androgen-Independent Progression in a Lineage-Derived Prostate Cancer Progression Model","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"LNCaP; Androgen receptor; Prostate cancer; Cancer research; Androgen; Endocrinology; Biology; Bicalutamide; Internal medicine; Tumor progression; Insulin-like growth factor; Growth factor; Protein kinase B; Signal transduction; Cancer; Receptor; Medicine; Cell biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008193369,0.0004125389,0.0007854832,0.0007257157,0.0002621476,0.00005783997,0.0002768237,0.0003624159,0.00006093198],"category_scores_gemma":[0.0002351041,0.0003203805,0.0001110905,0.0008805578,0.0003707409,0.0003572657,0.0003502113,0.001172844,0.00000621113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006837967,"about_ca_system_score_gemma":0.001029918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00139165,"about_ca_topic_score_gemma":0.00006675464,"domain_scores_codex":[0.9953823,0.0002950927,0.0008191079,0.0008908675,0.00168354,0.0009290622],"domain_scores_gemma":[0.9976622,0.00009116134,0.0003389545,0.0004124245,0.0008845843,0.0006106914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003792907,0.0007472372,0.1201323,0.0009112938,0.000050804,0.00007040414,0.002542156,0.0001671909,0.8683361,0.00000640315,0.0001083358,0.003134807],"study_design_scores_gemma":[0.009766157,0.0006710447,0.04818507,0.007071678,0.0000312682,0.000007616039,0.0005226324,0.001047863,0.9321044,0.0001101156,0.000112844,0.0003693137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892499,0.00726574,0.00004167842,0.0005567335,0.0001345211,0.002491916,0.0001547319,0.00007620811,0.00002852135],"genre_scores_gemma":[0.9927852,0.004779509,0.001156977,0.00008703531,0.0001322208,0.000820688,0.00009606946,0.00009403472,0.00004832421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07194725,"threshold_uncertainty_score":0.9999248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06546374376710422,"score_gpt":0.3681777605173215,"score_spread":0.3027140167502173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}