{"id":"W2100970263","doi":"10.1158/0008-5472.can-04-2446","title":"Increased Insulin-Like Growth Factor I Receptor Expression and Signaling Are Components of Androgen-Independent Progression in a Lineage-Derived Prostate Cancer Progression Model","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"LNCaP; Androgen receptor; Prostate cancer; Cancer research; Androgen; Endocrinology; Biology; Bicalutamide; Internal medicine; Tumor progression; Insulin-like growth factor; Growth factor; Protein kinase B; Signal transduction; Cancer; Receptor; Medicine; Cell biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124674,0.000455496,0.000173275,0.0005838561,0.0002475133,0.0002920406,0.000264474,0.0001628215,0.001619768],"category_scores_gemma":[0.00007836806,0.0001902371,0.0002250953,0.0002873038,0.0002246328,0.000189087,0.0001764106,0.0006769523,0.0003141093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004487928,"about_ca_system_score_gemma":0.0004015947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002164946,"about_ca_topic_score_gemma":0.004162017,"domain_scores_codex":[0.9998611,0.00001721307,0.00000880694,0.00002375675,0.00006065909,0.00002845088],"domain_scores_gemma":[0.999921,0.000006329845,0.00001653846,0.00001406281,0.00001102381,0.00003111603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001711801,0.00008518141,0.0006385293,0.00002761482,0.000004926047,0.00006782943,0.00001187298,0.00005990986,0.9972156,0.000155642,0.00007415688,0.001487518],"study_design_scores_gemma":[0.00003963805,0.0009731581,0.0221992,0.00001079915,0.00002510937,0.0007331485,0.00004410135,0.00130986,0.9702582,0.0001159956,0.004280108,0.00001056202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892753,0.00164689,0.004561,0.0001096885,0.00002519335,0.00007218748,0.0005830556,0.0001402086,0.003586555],"genre_scores_gemma":[0.9821484,0.001797205,0.006357993,0.00006401062,0.00001170635,0.00009700636,0.001833558,0.00001983618,0.007670272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002164946,"threshold_uncertainty_score":0.005418599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06546374376710422,"score_gpt":0.3681777605173215,"score_spread":0.3027140167502173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}