{"id":"W2101002427","doi":"10.1152/ajpregu.00319.2002","title":"5-Aminoimidazole-4-carboxamide 1-β-<scp>d</scp>-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms","year":2003,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Glycogenolysis; Glycogen; Glycogen phosphorylase; Allosteric regulation; Chemistry; AMPK; Activator (genetics); Endocrinology; Internal medicine; Phosphatase; Glycogen synthase; Intracellular; Adenosine; Adenosine monophosphate; Protein kinase A; Biochemistry; Phosphorylation; Enzyme; Biology; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287611,0.0003314091,0.0002323434,0.0001246974,0.00009103397,0.000190633,0.0002099684,0.0001849675,0.001062949],"category_scores_gemma":[0.0001274777,0.00008671057,0.0001897458,0.00009986239,0.0002621638,0.0001574101,0.0001029335,0.0004049171,0.000176542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001711348,"about_ca_system_score_gemma":0.0001540202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005704943,"about_ca_topic_score_gemma":0.0009104919,"domain_scores_codex":[0.9999223,0.00002031178,0.000007597504,0.00001521992,0.00001263388,0.00002196458],"domain_scores_gemma":[0.9999161,0.00002328796,0.00002888713,0.00001045,0.000007333573,0.00001394481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006631243,0.00004181064,0.0002792281,0.00004310282,0.000009638124,0.0000660689,0.000008201782,0.0000669312,0.9972569,0.00004418081,0.00002612327,0.00149458],"study_design_scores_gemma":[0.0001335693,0.002398828,0.009468088,0.00000925802,0.00004725656,0.0002370473,0.00003012491,0.00107221,0.9857469,0.00004411337,0.0008067485,0.000005920151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957397,0.002299,0.0008042332,0.00007508419,0.00002116524,0.00001504957,0.0001013595,0.00004978714,0.0008946524],"genre_scores_gemma":[0.9975223,0.0009779807,0.001000792,0.00005023659,0.00001839383,0.00001788593,0.0001333343,0.000006623781,0.0002724164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062949,"threshold_uncertainty_score":0.003555954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088885718380035,"score_gpt":0.2458947847655341,"score_spread":0.2350059275817338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}