{"id":"W2101002427","doi":"10.1152/ajpregu.00319.2002","title":"5-Aminoimidazole-4-carboxamide 1-β-<scp>d</scp>-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms","year":2003,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Glycogenolysis; Glycogen; Glycogen phosphorylase; Allosteric regulation; Chemistry; AMPK; Activator (genetics); Endocrinology; Internal medicine; Phosphatase; Glycogen synthase; Intracellular; Adenosine; Adenosine monophosphate; Protein kinase A; Biochemistry; Phosphorylation; Enzyme; Biology; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003465081,0.0007568573,0.00183816,0.0001864902,0.0002214457,0.00003579944,0.0005138033,0.000240365,0.00005107381],"category_scores_gemma":[0.0001855162,0.0005854858,0.0005442544,0.0003548703,0.001794745,0.0000431297,0.0001312515,0.0005116026,0.00001467721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005547461,"about_ca_system_score_gemma":0.000240492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000318127,"about_ca_topic_score_gemma":0.00001107119,"domain_scores_codex":[0.9958582,0.001367368,0.0008738555,0.0008602628,0.0002894999,0.0007508462],"domain_scores_gemma":[0.9970125,0.0003200165,0.001197653,0.0005241344,0.0006059127,0.0003397641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003101018,0.0001918449,0.0002105818,0.00001206007,0.001318233,0.000002055518,0.0006703581,0.0003455258,0.9881865,0.001408934,0.004941719,0.002402058],"study_design_scores_gemma":[0.002041698,0.00463447,0.01751286,0.00004726125,0.0003651186,0.00006282034,0.006743618,0.00007519655,0.9145246,0.00479402,0.04867034,0.0005279705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609657,0.03670756,0.001078478,0.00001997201,0.0004850928,0.0002533054,0.00008902731,0.00001516168,0.0003857194],"genre_scores_gemma":[0.9922345,0.004922781,0.001122432,0.0009946583,0.0004046634,0.00005132884,0.0000985546,0.0000468636,0.0001242465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07366189,"threshold_uncertainty_score":0.9996597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088885718380035,"score_gpt":0.2458947847655341,"score_spread":0.2350059275817338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}