{"id":"W2101006544","doi":"10.4049/jimmunol.0901099","title":"The p110δ Isoform of Phosphatidylinositol 3-Kinase Controls Susceptibility to <i>Leishmania major</i> by Regulating Expansion and Tissue Homing of Regulatory T Cells","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; University of Manitoba; Manitoba Health Research Council","keywords":"Biology; Leishmania major; Intracellular parasite; Effector; Cutaneous leishmaniasis; Homing (biology); Adoptive cell transfer; Immune system; Immunology; Leishmania; T cell; Intracellular; Cytokine; CTL*; Immunity; Cell biology; Leishmaniasis; CD8; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102459,0.0003618444,0.0001681285,0.0002369339,0.0001096912,0.0004299536,0.0003256525,0.0003053053,0.0004737482],"category_scores_gemma":[0.0001179435,0.0001888448,0.0001446123,0.0001248577,0.0004133143,0.000198617,0.0001951433,0.0005512525,0.0002590244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003109409,"about_ca_system_score_gemma":0.0001725163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003929639,"about_ca_topic_score_gemma":0.0003809315,"domain_scores_codex":[0.9998618,0.00001897363,0.00001396117,0.00004193481,0.00002247918,0.0000407351],"domain_scores_gemma":[0.999848,0.00001151622,0.00006698955,0.00001646247,0.000009041038,0.00004796375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002472179,0.00002658898,0.0006786665,0.00001672638,0.000003084012,0.00004024296,0.000007134636,0.00005195582,0.9976239,0.00009417518,0.00002906552,0.001181229],"study_design_scores_gemma":[0.0001033651,0.0007765537,0.02670872,0.000009928895,0.0000463217,0.0007548696,0.00006511035,0.001901601,0.9672538,0.0002639279,0.002101782,0.00001407995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971483,0.0006043379,0.001081105,0.00007681028,0.00001509446,0.00001229755,0.0001373833,0.00009233104,0.0008322987],"genre_scores_gemma":[0.9979995,0.0005376704,0.0004956878,0.00003758406,0.000008734437,0.00001178967,0.000152638,0.00001568565,0.0007407768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004737482,"threshold_uncertainty_score":0.002256036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00982301387860286,"score_gpt":0.2745879313497671,"score_spread":0.2647649174711642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}