{"id":"W2101019830","doi":"10.1128/aac.48.11.4405-4413.2004","title":"In Vitro Evolution of Itraconazole Resistance in <i>Aspergillus fumigatus</i> Involves Multiple Mechanisms of Resistance","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Itraconazole; Aspergillus fumigatus; Mutant; Efflux; Biology; Drug resistance; Microbiology; Selectable marker; Population; Antifungal drug; Gene; Genetics; Medicine; Candida albicans; Antifungal; Transformation (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796259,0.0004066995,0.0004423846,0.0001435932,0.0001631166,0.0003961567,0.0002961279,0.000302477,0.0004441836],"category_scores_gemma":[0.0002759189,0.0001759384,0.0004394117,0.0001799758,0.0001195519,0.0001455866,0.0002894069,0.0004119441,0.000323711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003872001,"about_ca_system_score_gemma":0.0001273815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003173621,"about_ca_topic_score_gemma":0.003396635,"domain_scores_codex":[0.9996821,0.00005715332,0.00005104074,0.00008565456,0.0000751793,0.00004894218],"domain_scores_gemma":[0.9997463,0.0000590051,0.00006442288,0.00005901163,0.00003881302,0.0000323988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003110703,0.00001533501,0.000879726,0.000009653849,0.000006953698,0.00002766617,0.00001007531,0.0001069233,0.9983316,0.00002053005,0.00001484072,0.0005457547],"study_design_scores_gemma":[0.00001020002,0.0004899498,0.02109052,0.000007127119,0.00004374534,0.000449517,0.00006829762,0.00234914,0.9741401,0.00003861124,0.001298118,0.00001460057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967192,0.0004634484,0.001687358,0.00004137103,0.00001349067,0.00002052018,0.0003510173,0.00003329782,0.0006702612],"genre_scores_gemma":[0.9953529,0.0002652998,0.002342043,0.00004561826,0.000006135597,0.0000277604,0.001114974,0.00002389742,0.0008213841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003173621,"threshold_uncertainty_score":0.006310284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008833678015592608,"score_gpt":0.2402911848920831,"score_spread":0.2314575068764905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}