{"id":"W2101021708","doi":"10.1016/j.ejca.2011.10.028","title":"Poor correlation between progression-free and overall survival in modern clinical trials: Are composite endpoints the answer?","year":2011,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Surrogate endpoint; Medicine; Clinical trial; Clinical endpoint; Progression-free survival; Internal medicine; Oncology; Quality of life (healthcare); Randomized controlled trial; Cancer; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.08182546,0.0001439547,0.001127259,0.0001830427,0.00009798969,0.00006210782,0.0003570385,0.00006050392,0.0001468027],"category_scores_gemma":[0.005690339,0.0001190337,0.0001746391,0.00008218462,0.00009757595,0.0003843853,0.00008428577,0.0004630145,0.0000658244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001420339,"about_ca_system_score_gemma":0.00009141159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009455954,"about_ca_topic_score_gemma":0.00008029565,"domain_scores_codex":[0.9888205,0.004513834,0.00603612,0.000259647,0.0001479556,0.0002219591],"domain_scores_gemma":[0.9913293,0.001756215,0.006331746,0.0002999862,0.0001066023,0.0001761703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001681479,0.0000648859,0.977446,0.00004041388,0.0001217363,0.00001401922,0.002513048,0.0000860553,0.00000124697,0.001032326,0.005405983,0.01310617],"study_design_scores_gemma":[0.002552279,0.0001368611,0.9816139,0.0002920878,0.00002434316,0.000007292968,0.0003033119,0.001471566,0.000002161551,0.0047944,0.008652658,0.000149083],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560258,0.01133445,0.005992034,0.01868746,0.002203939,0.0005232915,0.0001666422,0.0000138854,0.005052458],"genre_scores_gemma":[0.9942181,0.0008669684,0.001346561,0.001964099,0.001436928,0.000004900562,0.000002619404,0.00003400775,0.0001257867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07613511,"threshold_uncertainty_score":0.9454539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6241680414480324,"score_gpt":0.5047101953925927,"score_spread":0.1194578460554397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}