{"id":"W2101077684","doi":"10.1161/jaha.112.000810","title":"The Oxysterol 24 <i>(S)</i> ,25‐Epoxycholesterol Attenuates Human Smooth Muscle–Derived Foam Cell Formation Via Reduced Low‐Density Lipoprotein Uptake and Enhanced Cholesterol Efflux","year":2012,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Oxysterol; Foam cell; Lipoprotein; Internal medicine; Cholesteryl ester; Endocrinology; Receptor; LDL receptor; Low-density lipoprotein; Triglyceride; Cholesterol; Agonist; Apolipoprotein B; Biochemistry; Chemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001575484,0.0003568861,0.0002973189,0.0001802051,0.0001597583,0.0002490275,0.0001480928,0.0002338108,0.001380814],"category_scores_gemma":[0.000118516,0.0001266095,0.0002745792,0.0000664468,0.0002755561,0.0001212755,0.0001122938,0.0003887652,0.0003716716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001953054,"about_ca_system_score_gemma":0.0002114797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007114785,"about_ca_topic_score_gemma":0.0007895725,"domain_scores_codex":[0.9999027,0.00002118683,0.00001022552,0.0000137813,0.00001905601,0.00003294374],"domain_scores_gemma":[0.9999105,0.00001092441,0.00002052316,0.000008990529,0.00001367646,0.00003534574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006101642,0.0001020412,0.0002109178,0.0000303767,0.000009524056,0.00005449964,0.00002182371,0.0000235269,0.9974909,0.0000250325,0.00003243521,0.001388852],"study_design_scores_gemma":[0.0000712986,0.003453828,0.00500085,0.000006573678,0.000045592,0.0001671155,0.00004745445,0.0003668911,0.9895124,0.0000226935,0.001300414,0.000004995785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980343,0.0009195242,0.0004488835,0.0000444999,0.00002532966,0.00001063097,0.00004811339,0.00002492196,0.0004437266],"genre_scores_gemma":[0.9962336,0.0007994211,0.0007872717,0.00005465254,0.00002798332,0.00002463674,0.0002029817,0.00001004979,0.001859349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001380814,"threshold_uncertainty_score":0.004619241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064808908088433,"score_gpt":0.2519260281312581,"score_spread":0.2412779390503738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}