{"id":"W2101083042","doi":"10.1158/1055-9965.epi-08-0926","title":"Global DNA Hypomethylation (LINE-1) in the Normal Colon and Lifestyle Characteristics and Dietary and Genetic Factors","year":2009,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health","keywords":"DNA methylation; Genetics; Line (geometry); DNA; Biology; Gene; Gene expression; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008146222,0.000166226,0.0002180807,0.00004563663,0.0000968324,0.00001484477,0.00007201701,0.0002376337,0.000002785838],"category_scores_gemma":[0.0002859636,0.0001356617,0.00004106109,0.00009412702,0.0001487232,0.00001075285,0.00004376965,0.00007337215,2.330724e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002141687,"about_ca_system_score_gemma":0.00003020148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009046808,"about_ca_topic_score_gemma":0.0002757331,"domain_scores_codex":[0.9984585,0.0005191216,0.0003621681,0.0003744798,0.00005560105,0.0002301281],"domain_scores_gemma":[0.9994394,0.0001156778,0.0001856368,0.0001561607,0.00003202933,0.00007113131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001132987,0.00003029398,0.9076222,0.00001685657,0.00003875468,0.000001411277,0.00005904268,0.00001796463,0.02869129,0.00004024136,0.00006744192,0.0633012],"study_design_scores_gemma":[0.0003991794,0.0004563968,0.9939792,0.00002172511,0.00004869779,0.000006930702,0.00003424543,0.0004058471,0.0007544468,0.003115861,0.0006341246,0.0001433063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975889,0.02131416,0.001233551,0.001094428,0.0001260415,0.000281316,0.00002124019,0.000006118923,0.00003418811],"genre_scores_gemma":[0.9890621,0.00942587,0.0008339947,0.0003273438,0.0001250069,0.00002046774,0.0001791298,0.000006356524,0.00001970738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08635704,"threshold_uncertainty_score":0.5532125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03142614354151036,"score_gpt":0.3335783087140117,"score_spread":0.3021521651725013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}