{"id":"W2101116570","doi":"10.1093/hmg/ddq078","title":"Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Hospital for Sick Children; McGill University","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Biology; PTPN22; Genetics; Haplotype; Allele; Inflammatory bowel disease; Genome-wide association study; Major histocompatibility complex; Genetic predisposition; Single-nucleotide polymorphism; Autoimmunity; Locus (genetics); Disease; Genetic association; Immunology; Genotype; Gene; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006172679,0.0002301642,0.0002918432,0.0001119128,0.0000877526,0.0000363917,0.0001844258,0.0001293412,0.000008578126],"category_scores_gemma":[0.0000327215,0.0002158572,0.0001161135,0.0002173017,0.0002479725,0.000002914982,0.0001181069,0.0001160375,0.000001749897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004390738,"about_ca_system_score_gemma":0.00004399033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005919827,"about_ca_topic_score_gemma":0.0001009896,"domain_scores_codex":[0.9989021,0.0000615859,0.000208664,0.0003914795,0.0001529445,0.0002832157],"domain_scores_gemma":[0.9990233,0.00002281399,0.0001441052,0.000458719,0.0001585328,0.0001925643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000195189,0.00006185747,0.3474651,0.00003455414,0.0009329357,0.000003078865,0.00003939349,0.0008883273,0.6503325,0.00002633048,0.00004412163,0.0001522716],"study_design_scores_gemma":[0.0005545493,0.0003180858,0.7636709,0.000009859834,0.001098983,2.523962e-7,0.00002170069,0.00141157,0.2322812,0.00007296242,0.0002787598,0.0002812638],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959829,0.003430812,0.0001489862,0.00001301783,0.00002523068,0.0002743447,0.00003256057,0.00001207231,0.00008006459],"genre_scores_gemma":[0.998553,0.0001182461,0.0007847403,0.0001276766,0.00002461373,0.0000257302,0.0003139703,0.00003147922,0.00002051513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4180514,"threshold_uncertainty_score":0.88024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004237840989051487,"score_gpt":0.2276402263654944,"score_spread":0.2234023853764429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}