{"id":"W2101129972","doi":"10.1128/mcb.22.21.7645-7657.2002","title":"Rac2, a Hematopoiesis-Specific Rho GTPase, Specifically Regulates Mast Cell Protease Gene Expression in Bone Marrow-Derived Mast Cells","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; RAC1; Stem cell factor; Transcription factor; Mast cell; Cell biology; Haematopoiesis; Signal transduction; Regulation of gene expression; Gene expression; GTPase; Rac GTP-Binding Proteins; Molecular biology; Gene; Stem cell; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002646864,0.0004931916,0.0007038112,0.0002693729,0.0002092592,0.00003728204,0.0002982741,0.0006513515,0.004184688],"category_scores_gemma":[0.00001427951,0.0004458756,0.0001810035,0.0002194462,0.0005043721,0.00005272838,0.0002351857,0.0004784739,0.0005193782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003865152,"about_ca_system_score_gemma":0.00001720696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003227428,"about_ca_topic_score_gemma":0.000008046534,"domain_scores_codex":[0.9970187,0.0004684759,0.0006768329,0.0009649961,0.00006464996,0.000806349],"domain_scores_gemma":[0.9989027,0.0000568627,0.000213384,0.0006523428,0.00006084755,0.0001138311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001961915,0.0004794626,0.0002375572,0.00007677895,0.00002947144,0.0004123113,0.0002821614,0.000006382683,0.9958061,0.0003244588,0.001258465,0.0008906656],"study_design_scores_gemma":[0.002355531,0.0002444797,0.0001273265,0.00004054276,0.00002358681,0.00009005762,0.0001227458,0.00002138154,0.9297155,0.000187693,0.0665919,0.0004792442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449688,0.04677368,0.002770752,0.0002888598,0.0004064756,0.0007792748,0.00007062088,0.00008156847,0.003860033],"genre_scores_gemma":[0.9926564,0.0009140858,0.001543735,0.0002110043,0.00005256553,0.00007807744,0.0003442967,0.00005886978,0.004141009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06609058,"threshold_uncertainty_score":0.9997993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00835932806208655,"score_gpt":0.1776534276746347,"score_spread":0.1692940996125482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}